Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis)
Introduction: Secondary osteonecrosis of the knee affects younger population and has bilateral and extensive lesions. There is lack of evidence and a systematic review of literature on the treatment options is warranted. We aimed at identifying and analysing treatment options for secondary osteonecr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Journal of Orthopaedic Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773157X25000943 |
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| author | Vinay Joseph Joseph Boktor Stefan Bajada Ben Coupe |
| author_facet | Vinay Joseph Joseph Boktor Stefan Bajada Ben Coupe |
| author_sort | Vinay Joseph |
| collection | DOAJ |
| description | Introduction: Secondary osteonecrosis of the knee affects younger population and has bilateral and extensive lesions. There is lack of evidence and a systematic review of literature on the treatment options is warranted. We aimed at identifying and analysing treatment options for secondary osteonecrosis. Methods: A systematic review of literature was performed in accordance with the Cochrane handbook and reported according to the PRISMA guidelines. Analysis was performed using strategy of proportional meta-analysis. Results: A total of six studies were included with data on 240 knee joints in 192 patients were analysed. Follow up period ranged from 1 to 16 years. The mean age was 34.7. Three studies were on arthroplasty and three on joint preserving interventions. Steroid induced osteonecrosis was the majority. The pooled analysis showed an improvement of pre-operative knee score from 50.47 to 89.21 post-operatively. The pooled effect size for failure rate was 8.7 % in joint preserving interventions and 9.2 % in joint replacement group. Conclusion: Secondary knee osteonecrosis poses a therapeutic dilemma especially in early stages of osteonecrosis. Both joint preserving and joint replacement interventions do not show any significant or unacceptable complications. The results of this study will aid clinicians in the shared decision making process. |
| format | Article |
| id | doaj-art-2f5a4a56d3ae4bfd918c1e35e6dbb30d |
| institution | Kabale University |
| issn | 2773-157X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Reports |
| spelling | doaj-art-2f5a4a56d3ae4bfd918c1e35e6dbb30d2025-08-26T04:14:48ZengElsevierJournal of Orthopaedic Reports2773-157X2025-08-014210064210.1016/j.jorep.2025.100642Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis)Vinay Joseph0Joseph Boktor1Stefan Bajada2Ben Coupe3Registrar, Trauma and Orthopaedics, Wales Deanery, UK; Corresponding author.Registrar, Trauma and Orthopaedics, Wales Deanery, UKOrthopaedic Surgeon, Hywel Dda University, UKOrthopaedic Surgeon, Soft Tissue Knee and Sports Knee Surgery, Wrightington Hospital, UKIntroduction: Secondary osteonecrosis of the knee affects younger population and has bilateral and extensive lesions. There is lack of evidence and a systematic review of literature on the treatment options is warranted. We aimed at identifying and analysing treatment options for secondary osteonecrosis. Methods: A systematic review of literature was performed in accordance with the Cochrane handbook and reported according to the PRISMA guidelines. Analysis was performed using strategy of proportional meta-analysis. Results: A total of six studies were included with data on 240 knee joints in 192 patients were analysed. Follow up period ranged from 1 to 16 years. The mean age was 34.7. Three studies were on arthroplasty and three on joint preserving interventions. Steroid induced osteonecrosis was the majority. The pooled analysis showed an improvement of pre-operative knee score from 50.47 to 89.21 post-operatively. The pooled effect size for failure rate was 8.7 % in joint preserving interventions and 9.2 % in joint replacement group. Conclusion: Secondary knee osteonecrosis poses a therapeutic dilemma especially in early stages of osteonecrosis. Both joint preserving and joint replacement interventions do not show any significant or unacceptable complications. The results of this study will aid clinicians in the shared decision making process.http://www.sciencedirect.com/science/article/pii/S2773157X25000943 |
| spellingShingle | Vinay Joseph Joseph Boktor Stefan Bajada Ben Coupe Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) Journal of Orthopaedic Reports |
| title | Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) |
| title_full | Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) |
| title_fullStr | Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) |
| title_full_unstemmed | Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) |
| title_short | Treatment options for secondary osteonecrosis of the knee in young adults (Systematic review and meta-analysis) |
| title_sort | treatment options for secondary osteonecrosis of the knee in young adults systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2773157X25000943 |
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