Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model
The link between the gut environment and the prostate has recently been proposed as a potential therapeutic approach for treating benign prostatic hyperplasia (BPH). Therefore, this study examined the advantages of a novel oral probiotic supplement to improve intestinal health and treat BPH. A 3D in...
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MDPI AG
2024-11-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/22/3647 |
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| author | Sara Ferrari Rebecca Galla Simone Mulè Francesca Uberti |
| author_facet | Sara Ferrari Rebecca Galla Simone Mulè Francesca Uberti |
| author_sort | Sara Ferrari |
| collection | DOAJ |
| description | The link between the gut environment and the prostate has recently been proposed as a potential therapeutic approach for treating benign prostatic hyperplasia (BPH). Therefore, this study examined the advantages of a novel oral probiotic supplement to improve intestinal health and treat BPH. A 3D intestinal barrier model that simulated oral intake was used to analyse the combined regulative abilities of <i>Bifidobacterium longum</i> and <i>Bifidobacterium psychaerophilum</i>. Then, a co-culture prostatic model was used to investigate the biological consequences of the combination under conditions mimicking BPH. The results show the connection between the gut microbiome and prostate disease since the probiotics successfully modulate the primary mechanism involved in the pathogenesis of BPH. Indeed, after the intestinal passage, the mediators released from <i>B. longum</i> and <i>B. psychaerophilum</i> induced a substantial decrease in reactive oxidative species of about 6 times and inflammation (about 5 times regarding interleukine-6 and 10) and a sharp increase in testosterone and serotonin levels (about 95%). Further, proliferation and BPH principal mediators (such as androgen and dihydrotestosterone) were highly affected and nearly restored to physiological levels. Thus, BPH can be directly affected by probiotic supplementation; specifically, <i>B. longum</i> and <i>B. psychaerophilum</i>, in combination, seem able to promote the mitigation of this disease. |
| format | Article |
| id | doaj-art-2f595fafb71d4aa3af84d6e4c5732729 |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj-art-2f595fafb71d4aa3af84d6e4c57327292024-11-26T18:04:41ZengMDPI AGFoods2304-81582024-11-011322364710.3390/foods13223647Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture ModelSara Ferrari0Rebecca Galla1Simone Mulè2Francesca Uberti3Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, ItalyLaboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, ItalyLaboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, ItalyLaboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, ItalyThe link between the gut environment and the prostate has recently been proposed as a potential therapeutic approach for treating benign prostatic hyperplasia (BPH). Therefore, this study examined the advantages of a novel oral probiotic supplement to improve intestinal health and treat BPH. A 3D intestinal barrier model that simulated oral intake was used to analyse the combined regulative abilities of <i>Bifidobacterium longum</i> and <i>Bifidobacterium psychaerophilum</i>. Then, a co-culture prostatic model was used to investigate the biological consequences of the combination under conditions mimicking BPH. The results show the connection between the gut microbiome and prostate disease since the probiotics successfully modulate the primary mechanism involved in the pathogenesis of BPH. Indeed, after the intestinal passage, the mediators released from <i>B. longum</i> and <i>B. psychaerophilum</i> induced a substantial decrease in reactive oxidative species of about 6 times and inflammation (about 5 times regarding interleukine-6 and 10) and a sharp increase in testosterone and serotonin levels (about 95%). Further, proliferation and BPH principal mediators (such as androgen and dihydrotestosterone) were highly affected and nearly restored to physiological levels. Thus, BPH can be directly affected by probiotic supplementation; specifically, <i>B. longum</i> and <i>B. psychaerophilum</i>, in combination, seem able to promote the mitigation of this disease.https://www.mdpi.com/2304-8158/13/22/3647gut–prostate axisprobioticsoral supplementationco-culture prostatic model |
| spellingShingle | Sara Ferrari Rebecca Galla Simone Mulè Francesca Uberti Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model Foods gut–prostate axis probiotics oral supplementation co-culture prostatic model |
| title | Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model |
| title_full | Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model |
| title_fullStr | Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model |
| title_full_unstemmed | Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model |
| title_short | Analysis of the Beneficial Effects of Probiotics on the Gut–Prostate Axis Using Prostatic Co-Culture Model |
| title_sort | analysis of the beneficial effects of probiotics on the gut prostate axis using prostatic co culture model |
| topic | gut–prostate axis probiotics oral supplementation co-culture prostatic model |
| url | https://www.mdpi.com/2304-8158/13/22/3647 |
| work_keys_str_mv | AT saraferrari analysisofthebeneficialeffectsofprobioticsonthegutprostateaxisusingprostaticcoculturemodel AT rebeccagalla analysisofthebeneficialeffectsofprobioticsonthegutprostateaxisusingprostaticcoculturemodel AT simonemule analysisofthebeneficialeffectsofprobioticsonthegutprostateaxisusingprostaticcoculturemodel AT francescauberti analysisofthebeneficialeffectsofprobioticsonthegutprostateaxisusingprostaticcoculturemodel |