6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy

6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy

Abstract Background Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), and can cause severe cerebral complications and even fatality in children younger than 5 years old. However, there is no specific medication for EV71 infection in clinical practice...

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Bibliographic Details
Main Authors: Qiao You, Jing Wu, Ruining Lyu, Yurong Cai, Na Jiang, Ye Liu, Fang Zhang, Yating He, Deyan Chen, Zhiwei Wu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Microbiology
Subjects:
6-thioguanine (6-TG)
EV71
BIRC3
Autophagy
Online Access:https://doi.org/10.1186/s12866-025-03752-8
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