A stress paradox: the dual role of the unfolded protein response in the placenta
The placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic retic...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1525189/full |
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| author | Diba Chowdhury Chloe E. Jang Chloe E. Jang Chloe E. Jang Patrick Lajoie Patrick Lajoie Stephen J. Renaud Stephen J. Renaud |
| author_facet | Diba Chowdhury Chloe E. Jang Chloe E. Jang Chloe E. Jang Patrick Lajoie Patrick Lajoie Stephen J. Renaud Stephen J. Renaud |
| author_sort | Diba Chowdhury |
| collection | DOAJ |
| description | The placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic reticulum (ER), a dynamic organelle responsible for maintaining cellular protein and lipid synthesis and processing. ER stress occurs when there is an accumulation of unfolded or misfolded proteins, which triggers the activation of cellular pathways collectively called the unfolded protein response. Unfolded protein response pathways act to alleviate the misfolded protein burden and restore ER homeostasis, or if unresolved, initiate cell death. While prolonged ER stress has been linked to deficient placental function and adverse pregnancy outcomes, basal activation of unfolded protein response pathways is required for placental development and function. This review explores the importance of ER homeostasis in placental development and function, examining how disruptions in ER stress responses may contribute to adverse pregnancy outcomes. |
| format | Article |
| id | doaj-art-2f3faa65cb484e219e78569dc5c68b46 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-2f3faa65cb484e219e78569dc5c68b462024-12-20T05:10:26ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.15251891525189A stress paradox: the dual role of the unfolded protein response in the placentaDiba Chowdhury0Chloe E. Jang1Chloe E. Jang2Chloe E. Jang3Patrick Lajoie4Patrick Lajoie5Stephen J. Renaud6Stephen J. Renaud7Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaChildren’s Health Research Institute, Lawson Health Research Institute, London, ON, CanadaDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaChildren’s Health Research Institute, Lawson Health Research Institute, London, ON, CanadaDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, CanadaChildren’s Health Research Institute, Lawson Health Research Institute, London, ON, CanadaThe placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic reticulum (ER), a dynamic organelle responsible for maintaining cellular protein and lipid synthesis and processing. ER stress occurs when there is an accumulation of unfolded or misfolded proteins, which triggers the activation of cellular pathways collectively called the unfolded protein response. Unfolded protein response pathways act to alleviate the misfolded protein burden and restore ER homeostasis, or if unresolved, initiate cell death. While prolonged ER stress has been linked to deficient placental function and adverse pregnancy outcomes, basal activation of unfolded protein response pathways is required for placental development and function. This review explores the importance of ER homeostasis in placental development and function, examining how disruptions in ER stress responses may contribute to adverse pregnancy outcomes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1525189/fullER stressUPRplacentatrophoblastdecidua |
| spellingShingle | Diba Chowdhury Chloe E. Jang Chloe E. Jang Chloe E. Jang Patrick Lajoie Patrick Lajoie Stephen J. Renaud Stephen J. Renaud A stress paradox: the dual role of the unfolded protein response in the placenta Frontiers in Endocrinology ER stress UPR placenta trophoblast decidua |
| title | A stress paradox: the dual role of the unfolded protein response in the placenta |
| title_full | A stress paradox: the dual role of the unfolded protein response in the placenta |
| title_fullStr | A stress paradox: the dual role of the unfolded protein response in the placenta |
| title_full_unstemmed | A stress paradox: the dual role of the unfolded protein response in the placenta |
| title_short | A stress paradox: the dual role of the unfolded protein response in the placenta |
| title_sort | stress paradox the dual role of the unfolded protein response in the placenta |
| topic | ER stress UPR placenta trophoblast decidua |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1525189/full |
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