Roles of SPI-2 T3SS effectors in virulence of Salmonella Choleraesuis and Construction of a triple-gene mutant vaccine strain

Roles of SPI-2 T3SS effectors in virulence of Salmonella Choleraesuis and Construction of a triple-gene mutant vaccine strain

Effector protein functions of Type III secretion system (T3SS) encoded by Salmonella pathogenicity islands 2 (SPI-2) have not been fully characterized in Salmonella enterica serovar Choleraesuis. This study characterized 21 effectors of SPI-2 T3SS of S. Choleraesuis in terms of macrophage survival a...

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Bibliographic Details
Main Authors: Rui Xu, Xiangfei Ji, Junqi Lian, Dekang Zhu, Mafeng Liu, Mingshu Wang, Renyong Jia, Shun Chen, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng, Xinxin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Veterinary Science
Subjects:
S. choleraesuis
SPI-2
type III secretion system
virulence
vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1637327/full
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