Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent?
Aim: In this study, we aimed to determine the incidence and short term outcome of abnormal thyroid functions in children with newly diagnosed type 1 diabetes mellitus.Materials and Methods: Fourty-two patients with Type 1 diabetes mellitus who were diagnosed and observed in our department of pediatr...
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Galenos Publishing House
2008-06-01
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| Series: | Güncel Pediatri |
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| author | Tuğrul Karakuş Maşallah Candemir Serap Semiz |
| author_facet | Tuğrul Karakuş Maşallah Candemir Serap Semiz |
| author_sort | Tuğrul Karakuş |
| collection | DOAJ |
| description | Aim: In this study, we aimed to determine the incidence and short term outcome of abnormal thyroid functions in children with newly diagnosed type 1 diabetes mellitus.Materials and Methods: Fourty-two patients with Type 1 diabetes mellitus who were diagnosed and observed in our department of pediatrics between 2001-2006 were retrospectively evaluated. The thyroid function tests of the patients were measured within four and a half days of the initial diagnosis of diabetes and at least one follow-up test median on day 180 after diagnosis.Results: Twenty-two (52.4%) of the patients were female and 20 (47.6%) were male. Mean age of the patients was 9.4 (±3.6) years. Twenty-three patients (54.8%) were diagnosed as diabetic ketoacidosis, 15 (35.7%) as ketosis and 4 (9.5%) as hyperglycemia at the time of initial presentation. Thyroid functions were normal in 26 (61.9%) subjects. Thyroid function tests were abnormal in 16 (38.1%) subjects of whom 12 (75.0%) had biochemical findings compatible with sick euthyroid syndrome and of these 10 (83.3%) had diabetic ketoacidosis. All of these abnormalities were transient and thyroid function tests all returned to normal except for one patient. Antithyroid antibodies were positive in 7 (16.7%) subjects 2 (10.5%) with ketosis or hyperglycemia and 5 (21.7%) diabetic ketoacidosis. Thyroid function tests were abnormal in 6 (14.3.1%) subjects at follow-up. Thyroid disfunction rate decrased the 38.1% to 14.3% at the follow-up.Conclusion: This retrospective study revealed that abnormalities in thyroid function tests in subjects with newly diagnosed Type 1 diabetes mellitus were frequent and mostly transient. For this reason, in the absence of any clinical situation suggesting a thyroid disorder, we think it would be better to assess thyroid function tests at least one mouth after theinitial diagnosis of diabetes. (Journal of Current Pediatrics 2008; 6: 5-9) |
| format | Article |
| id | doaj-art-2f3e6426e2b94f4fb8e6d3daeb70ebfd |
| institution | Kabale University |
| issn | 1304-9054 |
| language | English |
| publishDate | 2008-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Güncel Pediatri |
| spelling | doaj-art-2f3e6426e2b94f4fb8e6d3daeb70ebfd2025-01-02T17:10:52ZengGalenos Publishing HouseGüncel Pediatri1304-90542008-06-016159Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent?Tuğrul KarakuşMaşallah CandemirSerap SemizAim: In this study, we aimed to determine the incidence and short term outcome of abnormal thyroid functions in children with newly diagnosed type 1 diabetes mellitus.Materials and Methods: Fourty-two patients with Type 1 diabetes mellitus who were diagnosed and observed in our department of pediatrics between 2001-2006 were retrospectively evaluated. The thyroid function tests of the patients were measured within four and a half days of the initial diagnosis of diabetes and at least one follow-up test median on day 180 after diagnosis.Results: Twenty-two (52.4%) of the patients were female and 20 (47.6%) were male. Mean age of the patients was 9.4 (±3.6) years. Twenty-three patients (54.8%) were diagnosed as diabetic ketoacidosis, 15 (35.7%) as ketosis and 4 (9.5%) as hyperglycemia at the time of initial presentation. Thyroid functions were normal in 26 (61.9%) subjects. Thyroid function tests were abnormal in 16 (38.1%) subjects of whom 12 (75.0%) had biochemical findings compatible with sick euthyroid syndrome and of these 10 (83.3%) had diabetic ketoacidosis. All of these abnormalities were transient and thyroid function tests all returned to normal except for one patient. Antithyroid antibodies were positive in 7 (16.7%) subjects 2 (10.5%) with ketosis or hyperglycemia and 5 (21.7%) diabetic ketoacidosis. Thyroid function tests were abnormal in 6 (14.3.1%) subjects at follow-up. Thyroid disfunction rate decrased the 38.1% to 14.3% at the follow-up.Conclusion: This retrospective study revealed that abnormalities in thyroid function tests in subjects with newly diagnosed Type 1 diabetes mellitus were frequent and mostly transient. For this reason, in the absence of any clinical situation suggesting a thyroid disorder, we think it would be better to assess thyroid function tests at least one mouth after theinitial diagnosis of diabetes. (Journal of Current Pediatrics 2008; 6: 5-9)http://www.guncelpediatri.com/yazilar.asp?yaziid=850&sayiid=Type 1 diabetes mellitusthyroid function test |
| spellingShingle | Tuğrul Karakuş Maşallah Candemir Serap Semiz Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent? Güncel Pediatri Type 1 diabetes mellitus thyroid function test |
| title | Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent? |
| title_full | Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent? |
| title_fullStr | Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent? |
| title_full_unstemmed | Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent? |
| title_short | Abnormalities of Thyroid Function in Children with Newly Diagnosed Type 1 Diabetes Mellitus: are Transient or Permanent? |
| title_sort | abnormalities of thyroid function in children with newly diagnosed type 1 diabetes mellitus are transient or permanent |
| topic | Type 1 diabetes mellitus thyroid function test |
| url | http://www.guncelpediatri.com/yazilar.asp?yaziid=850&sayiid= |
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