Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results
Background: Non-compact myocardium is a form of cardiomyopathy, which is characterized by an abnormal trabecular (non-compact) layer of the ventricular myocardium. The correlation between the severity of a non-compact myocardial layer and peculiarities of course and outcome of the disease remains un...
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"Paediatrician" Publishers LLC
2016-06-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1607 |
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| author | M. K. Umarova Ye. N. Basargina I. V. Silnova |
| author_facet | M. K. Umarova Ye. N. Basargina I. V. Silnova |
| author_sort | M. K. Umarova |
| collection | DOAJ |
| description | Background: Non-compact myocardium is a form of cardiomyopathy, which is characterized by an abnormal trabecular (non-compact) layer of the ventricular myocardium. The correlation between the severity of a non-compact myocardial layer and peculiarities of course and outcome of the disease remains unclear.Objective: Our aim was to examine the relationship of the ratio value of the non-compact and compact myocardial layer (NC/C) thickness, as well as of the number of non-compact segments of the left ventricle (LV) of the heart with the risk of death and thrombotic complications in children with dilated phenotype of non-compact myocardium.Methods: The results of a prospective cohort study, which included children hospitalized to a specialized hospital from October 2011 to May 2015, are presented. The presence of non-compact myocardium was established on the basis of echocardiography results.Results: The study included 48 children with non-compact myocardium and LV myocardium remodelling on the dilatation phenotype. Fatal outcome in 19 (8; 61) months from the date of detection of heart changes occurred in 11 (23%) cases. The development of thrombotic complications (cardioembolism, intravascular thrombosis before or during the observation) is recorded in 8 (17%) children. The risk of death and thrombotic complications did not depend on the NC/C value and the number of non-compact LV segments.Conclusion: The value of the ratio of NC/C and the number of non-compact LV myocardial segments does not allow to predict the course of the disease in children with dilated phenotype of non-compact myocardium in relation to the development of thrombotic complications and occurrence of fatal outcome. |
| format | Article |
| id | doaj-art-2f270847f2ec4fe6b4e751f628c5bc32 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | "Paediatrician" Publishers LLC |
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| series | Вопросы современной педиатрии |
| spelling | doaj-art-2f270847f2ec4fe6b4e751f628c5bc322025-08-20T03:59:49Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352016-06-0115216116710.15690/vsp.v15i2.15341578Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study ResultsM. K. Umarova0Ye. N. Basargina1I. V. Silnova2Scientific Centre of Children’s Health, Moscow, Russian FederationScientific Centre of Children’s Health, Moscow, Russian Federation I.M. Sechenov First Moscow State Medical University, Moscow, Russian FederationScientific Centre of Children’s Health, Moscow, Russian FederationBackground: Non-compact myocardium is a form of cardiomyopathy, which is characterized by an abnormal trabecular (non-compact) layer of the ventricular myocardium. The correlation between the severity of a non-compact myocardial layer and peculiarities of course and outcome of the disease remains unclear.Objective: Our aim was to examine the relationship of the ratio value of the non-compact and compact myocardial layer (NC/C) thickness, as well as of the number of non-compact segments of the left ventricle (LV) of the heart with the risk of death and thrombotic complications in children with dilated phenotype of non-compact myocardium.Methods: The results of a prospective cohort study, which included children hospitalized to a specialized hospital from October 2011 to May 2015, are presented. The presence of non-compact myocardium was established on the basis of echocardiography results.Results: The study included 48 children with non-compact myocardium and LV myocardium remodelling on the dilatation phenotype. Fatal outcome in 19 (8; 61) months from the date of detection of heart changes occurred in 11 (23%) cases. The development of thrombotic complications (cardioembolism, intravascular thrombosis before or during the observation) is recorded in 8 (17%) children. The risk of death and thrombotic complications did not depend on the NC/C value and the number of non-compact LV segments.Conclusion: The value of the ratio of NC/C and the number of non-compact LV myocardial segments does not allow to predict the course of the disease in children with dilated phenotype of non-compact myocardium in relation to the development of thrombotic complications and occurrence of fatal outcome.https://vsp.spr-journal.ru/jour/article/view/1607childrennon-compact myocardiumdilated cardiomyopathyfatal outcomethromboembolic complications |
| spellingShingle | M. K. Umarova Ye. N. Basargina I. V. Silnova Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results Вопросы современной педиатрии children non-compact myocardium dilated cardiomyopathy fatal outcome thromboembolic complications |
| title | Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results |
| title_full | Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results |
| title_fullStr | Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results |
| title_full_unstemmed | Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results |
| title_short | Correlation of Non-Compact Myocardial Layer Characteristics With the Risk of Death and Thrombotic Complications in Dilated Phenotype of Non-Compact Myocardium in Children: Cohort Study Results |
| title_sort | correlation of non compact myocardial layer characteristics with the risk of death and thrombotic complications in dilated phenotype of non compact myocardium in children cohort study results |
| topic | children non-compact myocardium dilated cardiomyopathy fatal outcome thromboembolic complications |
| url | https://vsp.spr-journal.ru/jour/article/view/1607 |
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