Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients
Objective: This study aimed to investigate the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in patients with early-stage gastric cancer and compare it with other immune markers, such as systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR),...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2025-01-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/assessment-of-the-cally-index-a-novel-immunonutrivite-marker-in-perioperatively-treated-gastric-cancer-patients/doi/gmj.2024.4197 |
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| author | Orhun Akdoğan Kadriye Bir Yücel Ozan Yazıcı Ahmet Özet Nuriye Özdemir |
| author_facet | Orhun Akdoğan Kadriye Bir Yücel Ozan Yazıcı Ahmet Özet Nuriye Özdemir |
| author_sort | Orhun Akdoğan |
| collection | DOAJ |
| description | Objective: This study aimed to investigate the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in patients with early-stage gastric cancer and compare it with other immune markers, such as systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), and prognostic nutritional index (PNI).
Methods: We retrospectively analyzed patients with early-stage gastric cancer who received adjuvant or perioperative chemotherapy. Laboratory results were obtained from the preoperative period. The CALLY index was calculated as follows: serum albumin level (g/dL) x absolute lymphocyte counts (109/L) / CRP (mg/dL) x104.
Results: A total of 74 patients were included in the study. The median relapse-free survival (RFS) was 13.0 (95 %CI: 7.7-18.2) months in the low CALLY index group and 38.2 (95% CI:18.4-57.8) months in the high CALLY index group (p<0.001). The median overall survival (OS) was 25.0 (95% CI: 17.1-32.8) months in the low CALLY index group and 60.4 (95% CI:45.8-74.1) months in the high-CALLY-index group (p<0.001). In multivariate cox regression analyses, a low CALLY index was an independent risk factor for both relapse-free survival (RFS) and OS.
Conclusion: The CALLY index was a prognostic factor for both RFS and OS, with a higher prognostic value than other prognostic factors (NLR, PNI, SII). |
| format | Article |
| id | doaj-art-2f07d3e4f6ed462a922a474dbeb2c396 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-2f07d3e4f6ed462a922a474dbeb2c3962025-01-13T11:48:11ZengGalenos Publishing HouseGazi Medical Journal2147-20922025-01-01361859010.12996/gmj.2024.4197Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer PatientsOrhun Akdoğan0https://orcid.org/0000-0003-0212-1191Kadriye Bir Yücel1https://orcid.org/0000-0002-4745-1605Ozan Yazıcı2https://orcid.org/0000-0003-2844-0959Ahmet Özet3https://orcid.org/0000-0001-8731-9636Nuriye Özdemir4https://orcid.org/0000-0002-9235-9592Department of Medical Oncology Gazi University, Ankara, TürkiyeDepartment of Medical Oncology Gazi University, Ankara, TürkiyeDepartment of Medical Oncology Gazi University, Ankara, TürkiyeDepartment of Medical Oncology Gazi University, Ankara, TürkiyeDepartment of Medical Oncology Gazi University, Ankara, TürkiyeObjective: This study aimed to investigate the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in patients with early-stage gastric cancer and compare it with other immune markers, such as systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), and prognostic nutritional index (PNI). Methods: We retrospectively analyzed patients with early-stage gastric cancer who received adjuvant or perioperative chemotherapy. Laboratory results were obtained from the preoperative period. The CALLY index was calculated as follows: serum albumin level (g/dL) x absolute lymphocyte counts (109/L) / CRP (mg/dL) x104. Results: A total of 74 patients were included in the study. The median relapse-free survival (RFS) was 13.0 (95 %CI: 7.7-18.2) months in the low CALLY index group and 38.2 (95% CI:18.4-57.8) months in the high CALLY index group (p<0.001). The median overall survival (OS) was 25.0 (95% CI: 17.1-32.8) months in the low CALLY index group and 60.4 (95% CI:45.8-74.1) months in the high-CALLY-index group (p<0.001). In multivariate cox regression analyses, a low CALLY index was an independent risk factor for both relapse-free survival (RFS) and OS. Conclusion: The CALLY index was a prognostic factor for both RFS and OS, with a higher prognostic value than other prognostic factors (NLR, PNI, SII).https://gazimedj.com/articles/assessment-of-the-cally-index-a-novel-immunonutrivite-marker-in-perioperatively-treated-gastric-cancer-patients/doi/gmj.2024.4197gastric cancercally indexalbuminlymphocytecrpprognostic |
| spellingShingle | Orhun Akdoğan Kadriye Bir Yücel Ozan Yazıcı Ahmet Özet Nuriye Özdemir Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients Gazi Medical Journal gastric cancer cally index albumin lymphocyte crp prognostic |
| title | Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients |
| title_full | Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients |
| title_fullStr | Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients |
| title_full_unstemmed | Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients |
| title_short | Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients |
| title_sort | assessment of the cally index a novel immunonutrivite marker in perioperatively treated gastric cancer patients |
| topic | gastric cancer cally index albumin lymphocyte crp prognostic |
| url | https://gazimedj.com/articles/assessment-of-the-cally-index-a-novel-immunonutrivite-marker-in-perioperatively-treated-gastric-cancer-patients/doi/gmj.2024.4197 |
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