A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity
Breast-conserving surgery accompanied by adjuvant radiotherapy is the standard of care for patients with early-stage breast cancer. However, re-excision is reported in 20–30 % of cases, largely because of close or involved tumor margins in the specimen. Several intraoperative tumor margin assessment...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024172969 |
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| author | Rowan W. Sanderson Renate Zilkens Peijun Gong Imogen Boman Ken Y. Foo Skandha Shanthakumar James Stephenson Wei Ling Ooi José Cid Fernandez Synn Lynn Chin Lee Jackson Mireille Hardie Benjamin F. Dessauvagie Anmol Rijhumal Saud Hamza Christobel M. Saunders Brendan F. Kennedy |
| author_facet | Rowan W. Sanderson Renate Zilkens Peijun Gong Imogen Boman Ken Y. Foo Skandha Shanthakumar James Stephenson Wei Ling Ooi José Cid Fernandez Synn Lynn Chin Lee Jackson Mireille Hardie Benjamin F. Dessauvagie Anmol Rijhumal Saud Hamza Christobel M. Saunders Brendan F. Kennedy |
| author_sort | Rowan W. Sanderson |
| collection | DOAJ |
| description | Breast-conserving surgery accompanied by adjuvant radiotherapy is the standard of care for patients with early-stage breast cancer. However, re-excision is reported in 20–30 % of cases, largely because of close or involved tumor margins in the specimen. Several intraoperative tumor margin assessment techniques have been proposed to overcome this issue, however, none have been widely adopted. Furthermore, tumor margin assessment of the excised specimen provides only an indirect indication of residual cancer in the patient following excision of the primary tumor. Handheld optical coherence tomography (OCT) probes and their functional extensions have the potential to detect residual cancer in vivo in the surgical cavity. Until now, validation of in vivo OCT has been achieved through correlation with ex vivo histology performed on the specimen removed during surgery that is adjacent to the tissue scanned in vivo. However, this indirect approach cannot accurately validate in vivo imaging performance. To address this, we present a method for robust co-registration of in vivo OCT scans with histology performed, not on the main specimen, but on cavity shavings corresponding directly to the tissue scanned in vivo. In this approach, we use ex vivo OCT scans as an intermediary, surgical sutures as fiducial markers, and extend the in vivo field-of-view to 15 × 15 mm2 by acquiring partially overlapping scans. We achieved successful co-registration of 78 % of 139 in vivo OCT scans from 16 patients. We present a detailed analysis of three cases, including a case where a functional extension of OCT, quantitative micro-elastography, was performed. |
| format | Article |
| id | doaj-art-2ef01efc3cd94b3cbdd39dcea2f37b34 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-2ef01efc3cd94b3cbdd39dcea2f37b342025-01-17T04:50:42ZengElsevierHeliyon2405-84402025-01-01111e41265A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavityRowan W. Sanderson0Renate Zilkens1Peijun Gong2Imogen Boman3Ken Y. Foo4Skandha Shanthakumar5James Stephenson6Wei Ling Ooi7José Cid Fernandez8Synn Lynn Chin9Lee Jackson10Mireille Hardie11Benjamin F. Dessauvagie12Anmol Rijhumal13Saud Hamza14Christobel M. Saunders15Brendan F. Kennedy16BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Perth, Australia; Corresponding author. BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia.BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia; Division of Surgery, Medical School, The University of Western Australia, Perth, Western Australia, AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Perth, AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Perth, Australia; OncoRes Medical, Perth, Western Australia, AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Perth, AustraliaOncoRes Medical, Perth, Western Australia, AustraliaBreast Centre, Fiona Stanley Hospital, Murdoch, Western Australia, AustraliaBreast Centre, Fiona Stanley Hospital, Murdoch, Western Australia, AustraliaBreast Centre, Fiona Stanley Hospital, Murdoch, Western Australia, AustraliaBreast Centre, Fiona Stanley Hospital, Murdoch, Western Australia, AustraliaBreast Centre, Fiona Stanley Hospital, Murdoch, Western Australia, AustraliaPathWest, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA, 6150, Australia; Division of Pathology and Laboratory Medicine, Medical School, The University of Western Australia, Perth, WA, 6009, AustraliaPathWest, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA, 6150, Australia; Division of Pathology and Laboratory Medicine, Medical School, The University of Western Australia, Perth, WA, 6009, Australia; Clinipath Pathology, Suite 1, 302 Selby Street North, Osborne Park, WA, 6017, AustraliaPathWest, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA, 6150, AustraliaBreast Centre, Fiona Stanley Hospital, Murdoch, Western Australia, AustraliaDivision of Surgery, Medical School, The University of Western Australia, Perth, Western Australia, Australia; Department of Surgery, Medical School, The University of Melbourne, Melbourne, Vic, AustraliaBRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia; Department of Electrical, Electronic and Computer Engineering, School of Engineering, The University of Western Australia, Perth, Australia; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Grudziadzka 5, 87-100, Torun, Poland; Australian Research Council Centre for Personalised Therapeutics Technologies, Melbourne, AustraliaBreast-conserving surgery accompanied by adjuvant radiotherapy is the standard of care for patients with early-stage breast cancer. However, re-excision is reported in 20–30 % of cases, largely because of close or involved tumor margins in the specimen. Several intraoperative tumor margin assessment techniques have been proposed to overcome this issue, however, none have been widely adopted. Furthermore, tumor margin assessment of the excised specimen provides only an indirect indication of residual cancer in the patient following excision of the primary tumor. Handheld optical coherence tomography (OCT) probes and their functional extensions have the potential to detect residual cancer in vivo in the surgical cavity. Until now, validation of in vivo OCT has been achieved through correlation with ex vivo histology performed on the specimen removed during surgery that is adjacent to the tissue scanned in vivo. However, this indirect approach cannot accurately validate in vivo imaging performance. To address this, we present a method for robust co-registration of in vivo OCT scans with histology performed, not on the main specimen, but on cavity shavings corresponding directly to the tissue scanned in vivo. In this approach, we use ex vivo OCT scans as an intermediary, surgical sutures as fiducial markers, and extend the in vivo field-of-view to 15 × 15 mm2 by acquiring partially overlapping scans. We achieved successful co-registration of 78 % of 139 in vivo OCT scans from 16 patients. We present a detailed analysis of three cases, including a case where a functional extension of OCT, quantitative micro-elastography, was performed.http://www.sciencedirect.com/science/article/pii/S2405844024172969 |
| spellingShingle | Rowan W. Sanderson Renate Zilkens Peijun Gong Imogen Boman Ken Y. Foo Skandha Shanthakumar James Stephenson Wei Ling Ooi José Cid Fernandez Synn Lynn Chin Lee Jackson Mireille Hardie Benjamin F. Dessauvagie Anmol Rijhumal Saud Hamza Christobel M. Saunders Brendan F. Kennedy A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity Heliyon |
| title | A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity |
| title_full | A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity |
| title_fullStr | A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity |
| title_full_unstemmed | A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity |
| title_short | A co-registration method to validate in vivo optical coherence tomography in the breast surgical cavity |
| title_sort | co registration method to validate in vivo optical coherence tomography in the breast surgical cavity |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024172969 |
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