Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site

Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site

Summary: Human CD4 (cluster of differentiation 4) is well known as the primary receptor for human immunodeficiency virus (HIV) entry into the cells. The virus binds to CD4 molecules to induce a conformational change in the viral glycoprotein (GP) gp120, which exposes the co-receptor binding site for...

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Bibliographic Details
Main Authors: Leah Liu Wang, Patrick Keiser, Derek Yang, Javier Seravalli, J.J. Patten, Brett Eaton, Dirk Anderson, Yi Liu, Michael R. Holbrook, Amos B. Smith, III, Robert A. Davey, Shi-Hua Xiang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Biological sciences
Immunology
Microbiology
Natural sciences
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422500834X
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