RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease
Introduction: The morbidity of recurrent focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) after transplant is well recognized. Additional collaborative research is necessary to advance understanding of recurrence epidemiology, mechanisms, interventions, and outco...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-12-01
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| Series: | Glomerular Diseases |
| Online Access: | https://karger.com/article/doi/10.1159/000542839 |
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| author | Eloise C. Salmon Ashley E. Rahimi Hailey E. Desmond Nathaniel M. Putnam Elena Martinelli Elizabeth M. Hendren Susan F. Massengill Priya S. Verghese Simone Sanna-Cherchi Matthias Kretzler Abhijit S. Naik Howard Trachtman Zubin J. Modi |
| author_facet | Eloise C. Salmon Ashley E. Rahimi Hailey E. Desmond Nathaniel M. Putnam Elena Martinelli Elizabeth M. Hendren Susan F. Massengill Priya S. Verghese Simone Sanna-Cherchi Matthias Kretzler Abhijit S. Naik Howard Trachtman Zubin J. Modi |
| author_sort | Eloise C. Salmon |
| collection | DOAJ |
| description |
Introduction: The morbidity of recurrent focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) after transplant is well recognized. Additional collaborative research is necessary to advance understanding of recurrence epidemiology, mechanisms, interventions, and outcomes, particularly in children. Methods: RESOLVE is a multicenter, observational cohort study examining the posttransplant course of patients with FSGS and MCD across the lifespan. Multiple enrollment options will facilitate both retrospective and prospective collection of biospecimens, self-report items, and electronic health record data across pediatric and adult participants. The study offers a unique mobile health option for participants to enroll and engage with the study remotely. Logistic regression using a log link function will evaluate recurrence risk within 3 months of transplant based on clinical characteristics and assess the impact of social determinants of health on time to graft failure, following adjustment. Cox proportional hazards models with primary outcome of graft failure with competing risk of death will evaluate the impact of recurrence therapy and access to preventative versus reactive recurrence therapy. Independent logistic regression will evaluate the impact of recurrence therapy and endophenotypes on proteinuric outcomes. Conclusion: Multiple enrollment approaches and tailored site participation are needed while studying recurrent FSGS (rFSGS) due to its rarity and phenotypic variability. RESOLVE provides a framework for international collaboration to unravel the course of rFSGS through a biospecimen and data repository. It also explores the potential for mobile health tools to enhance recruitment of participants and to promote cooperation among researchers to advance understanding of recurrence mechanisms and treatments. |
| format | Article |
| id | doaj-art-2ed008e51a6f4a6a8fc1a8d0e1861b9b |
| institution | DOAJ |
| issn | 2673-3633 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Glomerular Diseases |
| spelling | doaj-art-2ed008e51a6f4a6a8fc1a8d0e1861b9b2025-08-20T03:09:47ZengKarger PublishersGlomerular Diseases2673-36332024-12-0151606710.1159/000542839RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change DiseaseEloise C. SalmonAshley E. RahimiHailey E. DesmondNathaniel M. PutnamElena MartinelliElizabeth M. HendrenSusan F. Massengillhttps://orcid.org/0000-0002-3048-6983Priya S. VergheseSimone Sanna-CherchiMatthias KretzlerAbhijit S. NaikHoward TrachtmanZubin J. Modi Introduction: The morbidity of recurrent focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) after transplant is well recognized. Additional collaborative research is necessary to advance understanding of recurrence epidemiology, mechanisms, interventions, and outcomes, particularly in children. Methods: RESOLVE is a multicenter, observational cohort study examining the posttransplant course of patients with FSGS and MCD across the lifespan. Multiple enrollment options will facilitate both retrospective and prospective collection of biospecimens, self-report items, and electronic health record data across pediatric and adult participants. The study offers a unique mobile health option for participants to enroll and engage with the study remotely. Logistic regression using a log link function will evaluate recurrence risk within 3 months of transplant based on clinical characteristics and assess the impact of social determinants of health on time to graft failure, following adjustment. Cox proportional hazards models with primary outcome of graft failure with competing risk of death will evaluate the impact of recurrence therapy and access to preventative versus reactive recurrence therapy. Independent logistic regression will evaluate the impact of recurrence therapy and endophenotypes on proteinuric outcomes. Conclusion: Multiple enrollment approaches and tailored site participation are needed while studying recurrent FSGS (rFSGS) due to its rarity and phenotypic variability. RESOLVE provides a framework for international collaboration to unravel the course of rFSGS through a biospecimen and data repository. It also explores the potential for mobile health tools to enhance recruitment of participants and to promote cooperation among researchers to advance understanding of recurrence mechanisms and treatments. https://karger.com/article/doi/10.1159/000542839 |
| spellingShingle | Eloise C. Salmon Ashley E. Rahimi Hailey E. Desmond Nathaniel M. Putnam Elena Martinelli Elizabeth M. Hendren Susan F. Massengill Priya S. Verghese Simone Sanna-Cherchi Matthias Kretzler Abhijit S. Naik Howard Trachtman Zubin J. Modi RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease Glomerular Diseases |
| title | RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease |
| title_full | RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease |
| title_fullStr | RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease |
| title_full_unstemmed | RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease |
| title_short | RESOLVE: Recurrence Posttransplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease |
| title_sort | resolve recurrence posttransplant observational study in focal segmental glomerulosclerosis and minimal change disease |
| url | https://karger.com/article/doi/10.1159/000542839 |
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