An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection
Objective: This study aimed to compare clinical characteristics and quality of life (QoL) after vertebral osteomyelitis (VO) based on the status of pathogen detection in microbiological sampling. Methods: We conducted a post hoc data analysis from a prospective single-center study in a tertiary r...
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| Format: | Article |
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AVES
2024-03-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | https://www.aott.org.tr/en/an-investigation-into-the-quality-of-life-improvements-after-vertebral-osteomyelitis-depending-on-the-status-of-pathogen-detection-137387 |
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| _version_ | 1846161452105203712 |
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| author | Frank Beyer Birte Wenk Norma Jung Jan Bredow Peer Eysel Ayla Yagdiran |
| author_facet | Frank Beyer Birte Wenk Norma Jung Jan Bredow Peer Eysel Ayla Yagdiran |
| author_sort | Frank Beyer |
| collection | DOAJ |
| description | Objective: This study aimed to compare clinical characteristics and quality of life (QoL) after vertebral osteomyelitis (VO) based on the status of pathogen detection in microbiological sampling.
Methods: We conducted a post hoc data analysis from a prospective single-center study in a tertiary referral hospital, including VO patients from 2008 to 2020. Data were collected preoperatively (T0) and 1-year post surgery (T1). The primary outcome was QoL, assessed with the Oswestry Disability Index and Core Outcome Measures Index.
Results: Data from 133 patients with surgically treated thoracic or lumbar VO were evaluated. The pathogen was detected from cultured intraoperative samples in 100 (75.2%) patients (group 1). Culture remained negative in 33 (24.8%) patients (group 2). Quality of life did not differ significantly between the groups at T1. We observed higher preoperative C-reactive protein values and higher rates of spinal empyema at T0 in group 1.
Conclusion: Quality of life improved significantly for all patients at T1, but scores remained comparable to those reported by patients with chronic back pain. Quality of life was not affected by pathogen detection. However, attempts to detect pathogens are still indicated due to the concomitant findings, including bacteremia and epidural abscesses, along with the advantages of targeted antibiotic therapy. The most critical step for detection may be avoiding pre-sampling antibiotic administration. |
| format | Article |
| id | doaj-art-2ebd6d319fe64cfaad7cac525e47a51c |
| institution | Kabale University |
| issn | 1017-995X |
| language | English |
| publishDate | 2024-03-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj-art-2ebd6d319fe64cfaad7cac525e47a51c2024-11-21T06:17:59ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2024-03-0158213013410.5152/j.aott.2024.23073An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detectionFrank Beyer0Birte Wenk1Norma Jung2Jan Bredow3Peer Eysel4Ayla Yagdiran5Department of Orthopedics and Trauma Surgery, Krankenhaus Porz am Rhein, Cologne, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital of Cologne, Cologne, GermanyDepartment of Internal Medicine, University Hospital Cologne, Cologne, GermanyDepartment of Orthopedics and Trauma Surgery, Krankenhaus Porz am Rhein, Cologne, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital of Cologne, Cologne, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital of Cologne, Cologne, GermanyObjective: This study aimed to compare clinical characteristics and quality of life (QoL) after vertebral osteomyelitis (VO) based on the status of pathogen detection in microbiological sampling. Methods: We conducted a post hoc data analysis from a prospective single-center study in a tertiary referral hospital, including VO patients from 2008 to 2020. Data were collected preoperatively (T0) and 1-year post surgery (T1). The primary outcome was QoL, assessed with the Oswestry Disability Index and Core Outcome Measures Index. Results: Data from 133 patients with surgically treated thoracic or lumbar VO were evaluated. The pathogen was detected from cultured intraoperative samples in 100 (75.2%) patients (group 1). Culture remained negative in 33 (24.8%) patients (group 2). Quality of life did not differ significantly between the groups at T1. We observed higher preoperative C-reactive protein values and higher rates of spinal empyema at T0 in group 1. Conclusion: Quality of life improved significantly for all patients at T1, but scores remained comparable to those reported by patients with chronic back pain. Quality of life was not affected by pathogen detection. However, attempts to detect pathogens are still indicated due to the concomitant findings, including bacteremia and epidural abscesses, along with the advantages of targeted antibiotic therapy. The most critical step for detection may be avoiding pre-sampling antibiotic administration.https://www.aott.org.tr/en/an-investigation-into-the-quality-of-life-improvements-after-vertebral-osteomyelitis-depending-on-the-status-of-pathogen-detection-137387 |
| spellingShingle | Frank Beyer Birte Wenk Norma Jung Jan Bredow Peer Eysel Ayla Yagdiran An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection Acta Orthopaedica et Traumatologica Turcica |
| title | An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection |
| title_full | An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection |
| title_fullStr | An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection |
| title_full_unstemmed | An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection |
| title_short | An investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection |
| title_sort | investigation into the quality of life improvements after vertebral osteomyelitis depending on the status of pathogen detection |
| url | https://www.aott.org.tr/en/an-investigation-into-the-quality-of-life-improvements-after-vertebral-osteomyelitis-depending-on-the-status-of-pathogen-detection-137387 |
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