Growth and differentiation factors and their orthodontic implications: A scoping review
Background: Growth and differentiation factors (GDFs) are a class of biological mediators that play an important role to stimulate and regulate the wound healing process. Some of the GDFs are known to play a role in orthodontics. Objectives: To map the evidence related to GDFs in orthodontics and to...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-12-01
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| Series: | MethodsX |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221501612500281X |
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| author | Crystal Runa Soans M.S. Ravi Monisha P Chelery Sujata Shirodkar Prachi Pundir Shradha S. Parsekar |
| author_facet | Crystal Runa Soans M.S. Ravi Monisha P Chelery Sujata Shirodkar Prachi Pundir Shradha S. Parsekar |
| author_sort | Crystal Runa Soans |
| collection | DOAJ |
| description | Background: Growth and differentiation factors (GDFs) are a class of biological mediators that play an important role to stimulate and regulate the wound healing process. Some of the GDFs are known to play a role in orthodontics. Objectives: To map the evidence related to GDFs in orthodontics and to identify the role of GDFs in craniofacial morphogenesis, periodontal remodeling and orthodontic tooth movement. Methods: We have planned a scoping review to achieve the objectives. Search will be conducted in various databases to identify English language publications. Additionally, we will search the first ten pages of Google Scholar and the reference lists of included studies. This review will include all animal or human studies exploring preventive, interceptive and corrective treatments in orthodontics. Two reviewers will independently screen titles and abstracts and full-texts and extract the data of included studies. Disagreement will be resolved by discussion. The results will be presented in a descriptive format using diagrams and tables. Ethics and dissemination: The current study does not require ethical approval. Results of review findings will be disseminated through a peer-reviewed publication or conference presentation. Registration: The protocol is registered with the Open Science Framework. |
| format | Article |
| id | doaj-art-2ea7993550c94e31bf8fcd4979fba16a |
| institution | Kabale University |
| issn | 2215-0161 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | MethodsX |
| spelling | doaj-art-2ea7993550c94e31bf8fcd4979fba16a2025-08-20T03:26:31ZengElsevierMethodsX2215-01612025-12-011510343510.1016/j.mex.2025.103435Growth and differentiation factors and their orthodontic implications: A scoping reviewCrystal Runa Soans0M.S. Ravi1Monisha P Chelery2Sujata Shirodkar3Prachi Pundir4Shradha S. Parsekar5Department of orthodontics and dentofacial orthopedics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Mangalore, IndiaDepartment of orthodontics and dentofacial orthopedics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Mangalore, India; Corresponding author.Department of orthodontics and dentofacial orthopedics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Mangalore, IndiaCollaboration for Evidence Synthesis, Navelim, Goa, IndiaCollaboration for Evidence Synthesis, Navelim, Goa, India; The George Institute for Global Health, New Delhi, IndiaCollaboration for Evidence Synthesis, Navelim, Goa, India; Department of Healthcare Management, Goa Institute of Management, Sakhali-Poreim, Goa, IndiaBackground: Growth and differentiation factors (GDFs) are a class of biological mediators that play an important role to stimulate and regulate the wound healing process. Some of the GDFs are known to play a role in orthodontics. Objectives: To map the evidence related to GDFs in orthodontics and to identify the role of GDFs in craniofacial morphogenesis, periodontal remodeling and orthodontic tooth movement. Methods: We have planned a scoping review to achieve the objectives. Search will be conducted in various databases to identify English language publications. Additionally, we will search the first ten pages of Google Scholar and the reference lists of included studies. This review will include all animal or human studies exploring preventive, interceptive and corrective treatments in orthodontics. Two reviewers will independently screen titles and abstracts and full-texts and extract the data of included studies. Disagreement will be resolved by discussion. The results will be presented in a descriptive format using diagrams and tables. Ethics and dissemination: The current study does not require ethical approval. Results of review findings will be disseminated through a peer-reviewed publication or conference presentation. Registration: The protocol is registered with the Open Science Framework.http://www.sciencedirect.com/science/article/pii/S221501612500281XA protocol of a Scoping review |
| spellingShingle | Crystal Runa Soans M.S. Ravi Monisha P Chelery Sujata Shirodkar Prachi Pundir Shradha S. Parsekar Growth and differentiation factors and their orthodontic implications: A scoping review MethodsX A protocol of a Scoping review |
| title | Growth and differentiation factors and their orthodontic implications: A scoping review |
| title_full | Growth and differentiation factors and their orthodontic implications: A scoping review |
| title_fullStr | Growth and differentiation factors and their orthodontic implications: A scoping review |
| title_full_unstemmed | Growth and differentiation factors and their orthodontic implications: A scoping review |
| title_short | Growth and differentiation factors and their orthodontic implications: A scoping review |
| title_sort | growth and differentiation factors and their orthodontic implications a scoping review |
| topic | A protocol of a Scoping review |
| url | http://www.sciencedirect.com/science/article/pii/S221501612500281X |
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