Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study
Objective We investigated whether lifestyle affects assisted reproduction technology (ART) outcomes.Design Cohort study.Setting Italian fertility unit.Participants From September 2014 to December 2016, women from couples presenting for evaluation and eligible for ART were invited to participate. Inf...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-11-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e038837.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846151527636402176 |
|---|---|
| author | Carlo Agostoni Fabio Parazzini Edgardo Somigliana Elena Ricci Stefania Noli Stefania Ferrari Irene La Vecchia Valentina De Cosmi Marta Castiglioni Sonia Cipriani Paola Agnese Mauri |
| author_facet | Carlo Agostoni Fabio Parazzini Edgardo Somigliana Elena Ricci Stefania Noli Stefania Ferrari Irene La Vecchia Valentina De Cosmi Marta Castiglioni Sonia Cipriani Paola Agnese Mauri |
| author_sort | Carlo Agostoni |
| collection | DOAJ |
| description | Objective We investigated whether lifestyle affects assisted reproduction technology (ART) outcomes.Design Cohort study.Setting Italian fertility unit.Participants From September 2014 to December 2016, women from couples presenting for evaluation and eligible for ART were invited to participate. Information on alcohol intake, current smoking and leisure physical activity (PA) during the year before the interview was collected, using a structured questionnaire. We considered the ART outcomes of the cycle immediately following the interview.Primary and secondary outcome measures The primary outcome measure was cumulative pregnancy rate per retrieval. Secondary measures were number of retrieved oocytes, embryo transfer and live birth.Results In 492 women undergoing an ART cycle, 427 (86.8%) underwent embryo transfer, 157 (31.9%) had at least one clinical pregnancy and 121 (24.6%) had live birth. The cumulative pregnancy rate per retrieval was 33.3% (95% CI 28.5% to 38.7%). In women in the third tertile of alcohol intake, adjusted relative risk was 0.97 (95% CI 0.87 to 1.08), 0.90 (95% CI 0.62 to 1.30) and 0.89 (95% CI 0.57 to 1.37) for embryo transfer, clinical pregnancy and live birth, respectively. The corresponding figures in women currently smoking more than 5 cigarettes/day were 1.00 (95% CI 0.88 to 1.16), 0.94 (95% CI 0.60 to 1.48) and 1.14 (95% CI 0.68 to 1.90), and in women with PA ≥5 hours/week were 0.93 (95% CI 0.79 to 1.08), 0.44 (95% CI 0.22 to 0.90) and 0.48 (95% CI 0.22 to 1.05), respectively.Conclusion There were no significant differences in in vitro fertilisation outcomes among women who used alcohol or tobacco in the year prior to treatment. Conservatively, all women should be advised to limit substance abuse. Moreover, our study suggested that maintaining a moderate, but not high, level of PA could be beneficial. |
| format | Article |
| id | doaj-art-2e93039d0336477cbd1e4160891d9947 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-2e93039d0336477cbd1e4160891d99472024-11-27T09:15:12ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-038837Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort studyCarlo Agostoni0Fabio Parazzini1Edgardo Somigliana2Elena Ricci3Stefania Noli4Stefania Ferrari5Irene La Vecchia6Valentina De Cosmi7Marta Castiglioni8Sonia Cipriani9Paola Agnese Mauri102 Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Paediatric Intermediate Care Unit, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano Facoltà di Medicina e Chirurgia, Milano, Lombardia, ItalyDepartment of Gynecology and Obstetrics, Infertility Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano Facoltà di Medicina e Chirurgia, Milano, Lombardia, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyPediatric Intermediate Care Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyGynaecology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyObjective We investigated whether lifestyle affects assisted reproduction technology (ART) outcomes.Design Cohort study.Setting Italian fertility unit.Participants From September 2014 to December 2016, women from couples presenting for evaluation and eligible for ART were invited to participate. Information on alcohol intake, current smoking and leisure physical activity (PA) during the year before the interview was collected, using a structured questionnaire. We considered the ART outcomes of the cycle immediately following the interview.Primary and secondary outcome measures The primary outcome measure was cumulative pregnancy rate per retrieval. Secondary measures were number of retrieved oocytes, embryo transfer and live birth.Results In 492 women undergoing an ART cycle, 427 (86.8%) underwent embryo transfer, 157 (31.9%) had at least one clinical pregnancy and 121 (24.6%) had live birth. The cumulative pregnancy rate per retrieval was 33.3% (95% CI 28.5% to 38.7%). In women in the third tertile of alcohol intake, adjusted relative risk was 0.97 (95% CI 0.87 to 1.08), 0.90 (95% CI 0.62 to 1.30) and 0.89 (95% CI 0.57 to 1.37) for embryo transfer, clinical pregnancy and live birth, respectively. The corresponding figures in women currently smoking more than 5 cigarettes/day were 1.00 (95% CI 0.88 to 1.16), 0.94 (95% CI 0.60 to 1.48) and 1.14 (95% CI 0.68 to 1.90), and in women with PA ≥5 hours/week were 0.93 (95% CI 0.79 to 1.08), 0.44 (95% CI 0.22 to 0.90) and 0.48 (95% CI 0.22 to 1.05), respectively.Conclusion There were no significant differences in in vitro fertilisation outcomes among women who used alcohol or tobacco in the year prior to treatment. Conservatively, all women should be advised to limit substance abuse. Moreover, our study suggested that maintaining a moderate, but not high, level of PA could be beneficial.https://bmjopen.bmj.com/content/10/11/e038837.full |
| spellingShingle | Carlo Agostoni Fabio Parazzini Edgardo Somigliana Elena Ricci Stefania Noli Stefania Ferrari Irene La Vecchia Valentina De Cosmi Marta Castiglioni Sonia Cipriani Paola Agnese Mauri Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study BMJ Open |
| title | Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study |
| title_full | Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study |
| title_fullStr | Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study |
| title_full_unstemmed | Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study |
| title_short | Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study |
| title_sort | pretreatment maternal lifestyle and outcomes of assisted reproduction an italian cohort study |
| url | https://bmjopen.bmj.com/content/10/11/e038837.full |
| work_keys_str_mv | AT carloagostoni pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT fabioparazzini pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT edgardosomigliana pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT elenaricci pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT stefanianoli pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT stefaniaferrari pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT irenelavecchia pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT valentinadecosmi pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT martacastiglioni pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT soniacipriani pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy AT paolaagnesemauri pretreatmentmaternallifestyleandoutcomesofassistedreproductionanitaliancohortstudy |