Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling

Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling

Abstract Background Postoperative cognitive dysfunction (POCD) is a prevalent complication following anesthesia and surgery, particularly in the elderly, leading to increased mortality and reduced quality of life. Despite its prevalence, there are no effective clinical treatments. Exercise has shown...

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Bibliographic Details
Main Authors: Xiaodi Lu, Weijie Xiong, Zhuo Chen, Yurou Li, Fengyan Xu, Xue Yang, Meiwen Long, Wenhan Guo, Shuliang Wu, Liang Sun, Guonian Wang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
POCD
Exercise
Plasma
Cholinergic circuit
BDNF/TrkB
Online Access:https://doi.org/10.1186/s12964-024-01938-7
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