The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1
Background. It is unclear exactly how bariatric surgery affects the body’s metabolic and physiological functions. The purpose of the study was to assess the activity of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in obese individuals before and six months after laparoscopic s...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2024-10-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1440 |
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| author | Waseem Ahmed Alkatib Saad Ab-razaq Mijbas Nasser Madhlom Meazher Ahmed Jasim Muhsin Alghazaly Alaa Jumaah Manji Nasrawi |
| author_facet | Waseem Ahmed Alkatib Saad Ab-razaq Mijbas Nasser Madhlom Meazher Ahmed Jasim Muhsin Alghazaly Alaa Jumaah Manji Nasrawi |
| author_sort | Waseem Ahmed Alkatib |
| collection | DOAJ |
| description | Background. It is unclear exactly how bariatric surgery affects the body’s metabolic and physiological functions. The purpose of the study was to assess the activity of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in obese individuals before and six months after laparoscopic sleeve gastrectomy. Materials and methods. This study included 52 patients with a body mass index (BMI) ranging from 35 to 56 kg/m2 who qualified for laparoscopic sleeve gastrectomy and had completed data at the 6-month postoperative follow-up. All patients were clinically examined by a team of surgeons and a physician before operation. The serum levels of GH and IGF-1 were assessed pre- and post-operatively. Results. The study included 52 patients with obesity who were undergoing laparoscopic gastric sleeve surgery. Their mean age was 32.04 ± 6.90 years. More than half of the patients, 27 (51.9 %), were aged 19 to 32 years, 32 (61.5 %) patients were females, and 38 (73.1 %) had a BMI of 35–49.9 kg/m2. There was a significant increase in the serum GH after the sleeve gastrectomy compared to the pre-operative level (0.95 ± 0.30 vs 0.62 ± 0.40 ng/ml, p = 0.0001). IGF-1 also significantly increased after the surgery: 117.13 ± 32.40 vs 102.63 ± 33.90 ng/ml (p = 0.0001). Concerning BMI, there was no significant difference in the GH mean for patients with a BMI of 35–49.9 and 50–56 kg/m2 pre- and post-operatively: 0.6 vs 0.8 (p = 0.07) and 0.9 vs 1 (p = 0.5), respectively. On the other hand, IGF-1 exhibited a significant difference before and after surgery: 107.7 vs 88.9 ng/ml (p = 0.02) and 123.2 vs 100.7 (p = 0.03). Conclusions. This study concludes that sleeve gastrectomy significantly increases the serum level of both GH and IGF-1 and, consequently, their effects on disturbed lipid and protein metabolism in morbidly obese patients. |
| format | Article |
| id | doaj-art-2e7ac3ce1bc94ba299a771d60e9eb665 |
| institution | Kabale University |
| issn | 2224-0721 2307-1427 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj-art-2e7ac3ce1bc94ba299a771d60e9eb6652024-11-10T19:15:23ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272024-10-0120644344610.22141/2224-0721.20.6.2024.14401438The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1Waseem Ahmed Alkatib0https://orcid.org/0009-0003-6376-6281Saad Ab-razaq Mijbas1https://orcid.org/0000-0001-8176-5838Nasser Madhlom Meazher2https://orcid.org/0000-0001-5040-8977Ahmed Jasim Muhsin Alghazaly3Alaa Jumaah Manji Nasrawi4https://orcid.org/0000-0002-7638-2055Faculty of Medicine, University of Kufa, IraqFaculty of Medicine, University of Kufa, IraqFaculty of Medicine, University of Kufa, IraqAl-Najaf Health Directorate, Najaf, IraqFaculty of Medicine, University of Kufa, IraqBackground. It is unclear exactly how bariatric surgery affects the body’s metabolic and physiological functions. The purpose of the study was to assess the activity of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in obese individuals before and six months after laparoscopic sleeve gastrectomy. Materials and methods. This study included 52 patients with a body mass index (BMI) ranging from 35 to 56 kg/m2 who qualified for laparoscopic sleeve gastrectomy and had completed data at the 6-month postoperative follow-up. All patients were clinically examined by a team of surgeons and a physician before operation. The serum levels of GH and IGF-1 were assessed pre- and post-operatively. Results. The study included 52 patients with obesity who were undergoing laparoscopic gastric sleeve surgery. Their mean age was 32.04 ± 6.90 years. More than half of the patients, 27 (51.9 %), were aged 19 to 32 years, 32 (61.5 %) patients were females, and 38 (73.1 %) had a BMI of 35–49.9 kg/m2. There was a significant increase in the serum GH after the sleeve gastrectomy compared to the pre-operative level (0.95 ± 0.30 vs 0.62 ± 0.40 ng/ml, p = 0.0001). IGF-1 also significantly increased after the surgery: 117.13 ± 32.40 vs 102.63 ± 33.90 ng/ml (p = 0.0001). Concerning BMI, there was no significant difference in the GH mean for patients with a BMI of 35–49.9 and 50–56 kg/m2 pre- and post-operatively: 0.6 vs 0.8 (p = 0.07) and 0.9 vs 1 (p = 0.5), respectively. On the other hand, IGF-1 exhibited a significant difference before and after surgery: 107.7 vs 88.9 ng/ml (p = 0.02) and 123.2 vs 100.7 (p = 0.03). Conclusions. This study concludes that sleeve gastrectomy significantly increases the serum level of both GH and IGF-1 and, consequently, their effects on disturbed lipid and protein metabolism in morbidly obese patients.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1440growth hormoneinsulin-like growth factor 1sleeve gastrectomyobesity |
| spellingShingle | Waseem Ahmed Alkatib Saad Ab-razaq Mijbas Nasser Madhlom Meazher Ahmed Jasim Muhsin Alghazaly Alaa Jumaah Manji Nasrawi The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1 Mìžnarodnij Endokrinologìčnij Žurnal growth hormone insulin-like growth factor 1 sleeve gastrectomy obesity |
| title | The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1 |
| title_full | The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1 |
| title_fullStr | The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1 |
| title_full_unstemmed | The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1 |
| title_short | The effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin-like growth factor 1 |
| title_sort | effects of laparoscopic sleeve gastrectomy on serum levels of growth hormone and insulin like growth factor 1 |
| topic | growth hormone insulin-like growth factor 1 sleeve gastrectomy obesity |
| url | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1440 |
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