Experimental solubility of omeprazole in pure and ethanol-modified subcritical water
Abstract The current research aimed to study and measure the solubility of omeprazole (used to treat and reduce stomach acid) for the first time in pure subcritical and ethanol-modified water. These tests have been performed in the 25–130 °C temperature range and constant pressure of 20 bar with the...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-75829-9 |
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| author | Meysam Salehian Ali Haghighi Asl Maryam Khajenoori |
| author_facet | Meysam Salehian Ali Haghighi Asl Maryam Khajenoori |
| author_sort | Meysam Salehian |
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| description | Abstract The current research aimed to study and measure the solubility of omeprazole (used to treat and reduce stomach acid) for the first time in pure subcritical and ethanol-modified water. These tests have been performed in the 25–130 °C temperature range and constant pressure of 20 bar with the use of 0–10% ethanol weight as the cosolvent. The solubility of omeprazole in subcritical water ranged from 0.0697 × 10–4 to 5.843 × 10–4 mol fraction at temperatures from 25 to 130 °C, respectively. The highest solubility was obtained at 130 °C with a 10% ethanol weight as the cosolvent, which is indicative of a significant trend of improvement in omeprazole solubility with the increase in temperature and the use of ethanol cosolvent in various weight percentages. The solubility experimental data obtained were fitted using the semi-experimental and modified Apelblat linear model, and the findings revealed an excellent correlation between the experimental data and the data received from the linear and modified Apelblat model. Also, at the 25–130 °C temperature range, no degradation, phase transition, or other changes in the structure and physical state of the drug were observed. |
| format | Article |
| id | doaj-art-2e5e43b6df2644b7970e654f4de13a7b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-2e5e43b6df2644b7970e654f4de13a7b2024-11-24T12:20:12ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-75829-9Experimental solubility of omeprazole in pure and ethanol-modified subcritical waterMeysam Salehian0Ali Haghighi Asl1Maryam Khajenoori2Faculty of Chemical, Petroleum and Gas Engineering, Semnan UniversityFaculty of Chemical, Petroleum and Gas Engineering, Semnan UniversityFaculty of Chemical, Petroleum and Gas Engineering, Semnan UniversityAbstract The current research aimed to study and measure the solubility of omeprazole (used to treat and reduce stomach acid) for the first time in pure subcritical and ethanol-modified water. These tests have been performed in the 25–130 °C temperature range and constant pressure of 20 bar with the use of 0–10% ethanol weight as the cosolvent. The solubility of omeprazole in subcritical water ranged from 0.0697 × 10–4 to 5.843 × 10–4 mol fraction at temperatures from 25 to 130 °C, respectively. The highest solubility was obtained at 130 °C with a 10% ethanol weight as the cosolvent, which is indicative of a significant trend of improvement in omeprazole solubility with the increase in temperature and the use of ethanol cosolvent in various weight percentages. The solubility experimental data obtained were fitted using the semi-experimental and modified Apelblat linear model, and the findings revealed an excellent correlation between the experimental data and the data received from the linear and modified Apelblat model. Also, at the 25–130 °C temperature range, no degradation, phase transition, or other changes in the structure and physical state of the drug were observed.https://doi.org/10.1038/s41598-024-75829-9SolubilityOmeprazoleSubcritical waterEthanol |
| spellingShingle | Meysam Salehian Ali Haghighi Asl Maryam Khajenoori Experimental solubility of omeprazole in pure and ethanol-modified subcritical water Scientific Reports Solubility Omeprazole Subcritical water Ethanol |
| title | Experimental solubility of omeprazole in pure and ethanol-modified subcritical water |
| title_full | Experimental solubility of omeprazole in pure and ethanol-modified subcritical water |
| title_fullStr | Experimental solubility of omeprazole in pure and ethanol-modified subcritical water |
| title_full_unstemmed | Experimental solubility of omeprazole in pure and ethanol-modified subcritical water |
| title_short | Experimental solubility of omeprazole in pure and ethanol-modified subcritical water |
| title_sort | experimental solubility of omeprazole in pure and ethanol modified subcritical water |
| topic | Solubility Omeprazole Subcritical water Ethanol |
| url | https://doi.org/10.1038/s41598-024-75829-9 |
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