A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study
Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-09-01
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| Series: | International Journal of Food Properties |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2215475 |
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| author | Mustofa Ahda Irwandi Jaswir Alfi Khatib Qamar Uddin Ahmed Nurkhasanah Mahfudh Yunita Dewi Ardini |
| author_facet | Mustofa Ahda Irwandi Jaswir Alfi Khatib Qamar Uddin Ahmed Nurkhasanah Mahfudh Yunita Dewi Ardini |
| author_sort | Mustofa Ahda |
| collection | DOAJ |
| description | Herbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for reducing glucose. The mechanisms of action of different herbal medicines used might be also different. The reduction of blood glucose levels by Aloe vera, Andrographis paniculata, and Trigonella foenum-graecum through minimum 3 mechanisms of action, such as increased GLP-1 secretion and inhibited amylase, glucosidase, and SGLT 2. While Andrographis paniculata has more than 4 mechanisms of action, such as increasing GLP secretion, activating PPAR ɣ-receptor, and also inhibiting amylase, glucosidase, and SGLT 2 but it did not inhibit DPP 4 in diabetic patients. |
| format | Article |
| id | doaj-art-2e4c32ee8d064c02b1ddbcce45b8d03f |
| institution | Kabale University |
| issn | 1094-2912 1532-2386 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj-art-2e4c32ee8d064c02b1ddbcce45b8d03f2025-01-02T10:41:34ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-012611414142510.1080/10942912.2023.2215475A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical studyMustofa Ahda0Irwandi Jaswir1Alfi Khatib2Qamar Uddin Ahmed3Nurkhasanah Mahfudh4Yunita Dewi Ardini5Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaDepartment of Pharmaceutical Chemistry, International Islamic University Malaysia, Kuantan, MalaysiaDepartment of Pharmaceutical Chemistry, International Islamic University Malaysia, Kuantan, MalaysiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, IndonesiaPaediatric Dentistry and Dental Public Health Department, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, MalaysiaHerbal utilization, as an antidiabetes agent, is an interesting topic to find acceptable herbal drugs to decrease blood glucose levels. The aim of this review is to evaluate the potency of selected herbal medicines to reduce blood glucose levels and to identify the chemical compounds responsible for reducing glucose. The mechanisms of action of different herbal medicines used might be also different. The reduction of blood glucose levels by Aloe vera, Andrographis paniculata, and Trigonella foenum-graecum through minimum 3 mechanisms of action, such as increased GLP-1 secretion and inhibited amylase, glucosidase, and SGLT 2. While Andrographis paniculata has more than 4 mechanisms of action, such as increasing GLP secretion, activating PPAR ɣ-receptor, and also inhibiting amylase, glucosidase, and SGLT 2 but it did not inhibit DPP 4 in diabetic patients.https://www.tandfonline.com/doi/10.1080/10942912.2023.2215475Anti-diabetesherbal medicinesmechanisms of actionclinical study |
| spellingShingle | Mustofa Ahda Irwandi Jaswir Alfi Khatib Qamar Uddin Ahmed Nurkhasanah Mahfudh Yunita Dewi Ardini A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study International Journal of Food Properties Anti-diabetes herbal medicines mechanisms of action clinical study |
| title | A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study |
| title_full | A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study |
| title_fullStr | A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study |
| title_full_unstemmed | A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study |
| title_short | A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mechanisms of action, and clinical study |
| title_sort | review on selected herbal plants as alternative anti diabetes drugs chemical compositions mechanisms of action and clinical study |
| topic | Anti-diabetes herbal medicines mechanisms of action clinical study |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2215475 |
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