Incorporating immune cell surrogates into a full-thickness tissue equivalent of human skin to characterize dendritic cell activation

Incorporating immune cell surrogates into a full-thickness tissue equivalent of human skin to characterize dendritic cell activation

Abstract In the past decades studies investigating the dendritic cell (DC) activation have been conducted almost exclusively in animal models. However, due to species-specific differences in the DC subsets, there is an urgent need for alternative in vitro models allowing the investigation of Langerh...

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Bibliographic Details
Main Authors: Johanna Maria Hölken, Anna-Lena Wurz, Katja Friedrich, Patricia Böttcher, Dounia Asskali, Holger Stark, Jörg Breitkreutz, Timo Buhl, Lars Vierkotten, Karsten Rüdiger Mewes, Nicole Teusch
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Full-thickness skin model
Skin equivalent
Langerhans cells
Dermal dendritic cells
CD1a
CD207
Online Access:https://doi.org/10.1038/s41598-024-81014-9
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