There exists only one tumor necrosis factor
Tumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2021-01-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/2179 |
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| _version_ | 1849240787337871360 |
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| author | S. A. Nedospasov |
| author_facet | S. A. Nedospasov |
| author_sort | S. A. Nedospasov |
| collection | DOAJ |
| description | Tumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this cytokine is a target of commonly used anti-cytokine therapy in autoimmune and inflammatory diseases. In scientific literature and textbooks TNF is often goes as “TNFa”, implying the existence of at least TNFβ (indeed, such term was used for about 10 years in 80s and 90s to designate lymphotoxin). However, already 25 years ago such designation of lymphotoxin was cancelled “on scientific grounds”. Therefore, both in Russian and in English the term TNF should be used without “alpha”. Labels of the reagents related to TNFb that are offered by commercial companies are misleading. |
| format | Article |
| id | doaj-art-2e3a5c7da13c4448bf77f5be2373962c |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2021-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-2e3a5c7da13c4448bf77f5be2373962c2025-08-20T04:00:26ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2021-01-012261221122410.15789/1563-0625-TEO-0001351There exists only one tumor necrosis factorS. A. Nedospasov0Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Lomonosov Moscow State University; Sirius University of Science and TechnologyTumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this cytokine is a target of commonly used anti-cytokine therapy in autoimmune and inflammatory diseases. In scientific literature and textbooks TNF is often goes as “TNFa”, implying the existence of at least TNFβ (indeed, such term was used for about 10 years in 80s and 90s to designate lymphotoxin). However, already 25 years ago such designation of lymphotoxin was cancelled “on scientific grounds”. Therefore, both in Russian and in English the term TNF should be used without “alpha”. Labels of the reagents related to TNFb that are offered by commercial companies are misleading.https://www.mimmun.ru/mimmun/article/view/2179tumor necrosis factorlymphotoxincytokinesredundancy |
| spellingShingle | S. A. Nedospasov There exists only one tumor necrosis factor Медицинская иммунология tumor necrosis factor lymphotoxin cytokines redundancy |
| title | There exists only one tumor necrosis factor |
| title_full | There exists only one tumor necrosis factor |
| title_fullStr | There exists only one tumor necrosis factor |
| title_full_unstemmed | There exists only one tumor necrosis factor |
| title_short | There exists only one tumor necrosis factor |
| title_sort | there exists only one tumor necrosis factor |
| topic | tumor necrosis factor lymphotoxin cytokines redundancy |
| url | https://www.mimmun.ru/mimmun/article/view/2179 |
| work_keys_str_mv | AT sanedospasov thereexistsonlyonetumornecrosisfactor |