REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA
Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-a...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Столичная издательская компания
2016-01-01
|
| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/938 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849227778292973568 |
|---|---|
| author | M. V. Pokrovsky N. G. Filipenko M. V. Korokin V. V. Gureyev T. G. Pokrovsky A. A. Barsuk L. V. Korokina E. V. Proskuryakova N. V. Maltseva O. V. Levashova O. S. Gudyrev A. S. Belous O. S. Polyanskaya |
| author_facet | M. V. Pokrovsky N. G. Filipenko M. V. Korokin V. V. Gureyev T. G. Pokrovsky A. A. Barsuk L. V. Korokina E. V. Proskuryakova N. V. Maltseva O. V. Levashova O. S. Gudyrev A. S. Belous O. S. Polyanskaya |
| author_sort | M. V. Pokrovsky |
| collection | DOAJ |
| description | Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-arginine increases the activity of eNOS and production of nitric oxide in the ADMA-similar model of L-NAME-induced endothelial dysfunction. ENOS activator (resveratrol), antioxidants, potentiated polyclonal antibodies to eNOS and others agents have been effective in this model. Studies of endotelioprotective activity in other «ADMA-eNOS-associated" experimental models of metabolic syndrome and homocysteine-induced, gipoestrogen-induced sepsis-induced endothelial dysfunction and endothelial dysfunction in postvaccinal vasculitis have been developed. |
| format | Article |
| id | doaj-art-2e2d0fe97be247eeb5bcd3a592b1aee3 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-2e2d0fe97be247eeb5bcd3a592b1aee32025-08-23T10:00:24ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-016688288710.20996/1819-6446-2010-6-6-882-887937REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIAM. V. Pokrovsky0N. G. Filipenko1M. V. Korokin2V. V. Gureyev3T. G. Pokrovsky4A. A. Barsuk5L. V. Korokina6E. V. Proskuryakova7N. V. Maltseva8O. V. Levashova9O. S. Gudyrev10A. S. Belous11O. S. Polyanskaya12Kursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityMethylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA is one of the predictors of preeclampsia. L-arginine increases the activity of eNOS and production of nitric oxide in the ADMA-similar model of L-NAME-induced endothelial dysfunction. ENOS activator (resveratrol), antioxidants, potentiated polyclonal antibodies to eNOS and others agents have been effective in this model. Studies of endotelioprotective activity in other «ADMA-eNOS-associated" experimental models of metabolic syndrome and homocysteine-induced, gipoestrogen-induced sepsis-induced endothelial dysfunction and endothelial dysfunction in postvaccinal vasculitis have been developed.https://www.rpcardio.online/jour/article/view/938endothelial dysfunctionpreeclampsiaadmaenos |
| spellingShingle | M. V. Pokrovsky N. G. Filipenko M. V. Korokin V. V. Gureyev T. G. Pokrovsky A. A. Barsuk L. V. Korokina E. V. Proskuryakova N. V. Maltseva O. V. Levashova O. S. Gudyrev A. S. Belous O. S. Polyanskaya REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA Рациональная фармакотерапия в кардиологии endothelial dysfunction preeclampsia adma enos |
| title | REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA |
| title_full | REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA |
| title_fullStr | REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA |
| title_full_unstemmed | REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA |
| title_short | REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA |
| title_sort | realities and prospects for pharmacological correction of adma enos associated ways in preeclampsia |
| topic | endothelial dysfunction preeclampsia adma enos |
| url | https://www.rpcardio.online/jour/article/view/938 |
| work_keys_str_mv | AT mvpokrovsky realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT ngfilipenko realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT mvkorokin realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT vvgureyev realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT tgpokrovsky realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT aabarsuk realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT lvkorokina realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT evproskuryakova realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT nvmaltseva realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT ovlevashova realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT osgudyrev realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT asbelous realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia AT ospolyanskaya realitiesandprospectsforpharmacologicalcorrectionofadmaenosassociatedwaysinpreeclampsia |