Structural basis of orientated asymmetry in a mGlu heterodimer

Structural basis of orientated asymmetry in a mGlu heterodimer

Abstract The structural basis for the allosteric interactions within G protein-coupled receptors (GPCRs) heterodimers remains largely unknown. The metabotropic glutamate (mGlu) receptors are complex dimeric GPCRs important for the fine tuning of many synapses. Heterodimeric mGlu receptors with speci...

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Main Authors: Weizhu Huang, Nan Jin, Jia Guo, Cangsong Shen, Chanjuan Xu, Kun Xi, Léo Bonhomme, Robert B. Quast, Dan-Dan Shen, Jiao Qin, Yi-Ru Liu, Yuxuan Song, Yang Gao, Emmanuel Margeat, Philippe Rondard, Jean-Philippe Pin, Yan Zhang, Jianfeng Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54744-7
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https://doi.org/10.1038/s41467-024-54744-7

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