Luteolin ameliorates rat model of metabolic syndrome-induced cardiac injury by apoptosis suppression and autophagy promotion via NR4A2/p53 regulation

Luteolin ameliorates rat model of metabolic syndrome-induced cardiac injury by apoptosis suppression and autophagy promotion via NR4A2/p53 regulation

Abstract Background Reduced cardiac autophagy, inflammation, and apoptosis contribute to cardiovascular complications caused by metabolic syndrome (MetS). It is documented that the nuclear receptor 4A2 (NR4A2) could modulate autophagy and apoptosis in cardiac complications. The aim of this investiga...

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Bibliographic Details
Main Authors: Xiyan Dai, Bo Liang, Yaolin Sun
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Metabolic syndrome
Cardiac
Autophagy
Apoptosis
Inflammation
Online Access:https://doi.org/10.1186/s12906-025-04749-6
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