Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains
Bovine genital leptospirosis (BGL) is a silent and chronic reproductive syndrome associated with reproductive failures that result in animal suffering and substantial financial losses for farmers. Important aspects of the interactions between the host and the pathogen during chronic leptospirosis ha...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1517151/full |
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| author | Maria Isabel Nogueira Di Azevedo Frederico Kremer Camila Ezepha João Pedro Gomes Greco Isadora Cosenza Vieira da Silva Pascale Bourhy Walter Lilenbaum |
| author_facet | Maria Isabel Nogueira Di Azevedo Frederico Kremer Camila Ezepha João Pedro Gomes Greco Isadora Cosenza Vieira da Silva Pascale Bourhy Walter Lilenbaum |
| author_sort | Maria Isabel Nogueira Di Azevedo |
| collection | DOAJ |
| description | Bovine genital leptospirosis (BGL) is a silent and chronic reproductive syndrome associated with reproductive failures that result in animal suffering and substantial financial losses for farmers. Important aspects of the interactions between the host and the pathogen during chronic leptospirosis have been well described in the kidney, but little is known about the genital infection mechanisms. The present study sheds light on the pathophysiology of BGL based on comparative genomic analysis of renal versus genital isolates of Leptospira santarosai genomes, an endemic species on Latin America. A significant number of genes were exclusive of the genital strains, with emphasis on genes associated with cell wall/membrane/envelope biogenesis, mobilome: prophages and transposons, and signal transduction mechanisms. Overall, these gene clusters play crucial roles in bacterial colonization and evasion of the immune response, which can reflect leptospiral tissue tropism to the genital niche. We provide new insights into the pathophysiology of an important and neglected syndrome in bovine, helping to elucidate the evolution of adaptation of leptospires in the genital tract of cows. |
| format | Article |
| id | doaj-art-2e0e5a53bb60420da68ad02d35c0ce6b |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-2e0e5a53bb60420da68ad02d35c0ce6b2025-01-07T06:47:44ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011510.3389/fmicb.2024.15171511517151Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strainsMaria Isabel Nogueira Di Azevedo0Frederico Kremer1Camila Ezepha2João Pedro Gomes Greco3Isadora Cosenza Vieira da Silva4Pascale Bourhy5Walter Lilenbaum6Laboratory of Veterinary Bacteriology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, BrazilLaboratory of Bioinformatics - Omixlab, Technological Development Center, Federal University of Pelotas, Capão do Leão, Rio Grande do Sul, BrazilLaboratory of Veterinary Bacteriology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, BrazilLaboratory of Bioinformatics - Omixlab, Technological Development Center, Federal University of Pelotas, Capão do Leão, Rio Grande do Sul, BrazilLaboratory of Bioinformatics - Omixlab, Technological Development Center, Federal University of Pelotas, Capão do Leão, Rio Grande do Sul, BrazilInstitut Pasteur, Biology of Spirochetes Unit, National Reference Center for Leptospirosis, Paris, FranceLaboratory of Veterinary Bacteriology, Biomedical Institute, Fluminense Federal University, Niterói, Rio de Janeiro, BrazilBovine genital leptospirosis (BGL) is a silent and chronic reproductive syndrome associated with reproductive failures that result in animal suffering and substantial financial losses for farmers. Important aspects of the interactions between the host and the pathogen during chronic leptospirosis have been well described in the kidney, but little is known about the genital infection mechanisms. The present study sheds light on the pathophysiology of BGL based on comparative genomic analysis of renal versus genital isolates of Leptospira santarosai genomes, an endemic species on Latin America. A significant number of genes were exclusive of the genital strains, with emphasis on genes associated with cell wall/membrane/envelope biogenesis, mobilome: prophages and transposons, and signal transduction mechanisms. Overall, these gene clusters play crucial roles in bacterial colonization and evasion of the immune response, which can reflect leptospiral tissue tropism to the genital niche. We provide new insights into the pathophysiology of an important and neglected syndrome in bovine, helping to elucidate the evolution of adaptation of leptospires in the genital tract of cows.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1517151/fullleptospirosisBGLveterinary microbiologyWGSinfectious disease |
| spellingShingle | Maria Isabel Nogueira Di Azevedo Frederico Kremer Camila Ezepha João Pedro Gomes Greco Isadora Cosenza Vieira da Silva Pascale Bourhy Walter Lilenbaum Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains Frontiers in Microbiology leptospirosis BGL veterinary microbiology WGS infectious disease |
| title | Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains |
| title_full | Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains |
| title_fullStr | Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains |
| title_full_unstemmed | Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains |
| title_short | Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains |
| title_sort | comparative genomics of leptospira santarosai reveals genomic adaptations in bovine genital strains |
| topic | leptospirosis BGL veterinary microbiology WGS infectious disease |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1517151/full |
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