Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI
The aim of this study is to evaluate the localization of 99m Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered 99m Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localizat...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-01-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012116689001 |
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| author | In Joon Lee MD, PhD Ji Yong Park MS Young-il Kim MD, PhD Yun-Sang Lee PhD Jae Min Jeong PhD Jaeil Kim BS Euishin Edmund Kim MD, PhD Keon Wook Kang MD, PhD Dong Soo Lee MD, PhD Seonji Jeong MD Eun Jeong Kim BS Young Il Kim MD, PhD Jin Wook Chung MD, PhD |
| author_facet | In Joon Lee MD, PhD Ji Yong Park MS Young-il Kim MD, PhD Yun-Sang Lee PhD Jae Min Jeong PhD Jaeil Kim BS Euishin Edmund Kim MD, PhD Keon Wook Kang MD, PhD Dong Soo Lee MD, PhD Seonji Jeong MD Eun Jeong Kim BS Young Il Kim MD, PhD Jin Wook Chung MD, PhD |
| author_sort | In Joon Lee MD, PhD |
| collection | DOAJ |
| description | The aim of this study is to evaluate the localization of 99m Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered 99m Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of 99m Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs. Intra-arterial delivery of SPIO with Lipiodol might be a good drug delivery system targeting the hepatic tumors, as confirmed by image-based analysis. |
| format | Article |
| id | doaj-art-2dec4c8b3b4e453c9360d4a485d4ef7b |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-2dec4c8b3b4e453c9360d4a485d4ef7b2025-01-02T22:37:55ZengSAGE PublishingMolecular Imaging1536-01212017-01-011610.1177/153601211668900110.1177_1536012116689001Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRIIn Joon Lee MD, PhD0Ji Yong Park MS1Young-il Kim MD, PhD2Yun-Sang Lee PhD3Jae Min Jeong PhD4Jaeil Kim BS5Euishin Edmund Kim MD, PhD6Keon Wook Kang MD, PhD7Dong Soo Lee MD, PhD8Seonji Jeong MD9Eun Jeong Kim BS10Young Il Kim MD, PhD11Jin Wook Chung MD, PhD12 Department of Radiology, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea Department of Transdisciplinary Studies, Program in Biomedical Radiation Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Radiological Sciences, University of California, Irvine, USA Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea Department of Radiology, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab Emirate Department of Radiology, Seoul National University Hospital, Seoul, Republic of KoreaThe aim of this study is to evaluate the localization of 99m Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered 99m Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of 99m Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs. Intra-arterial delivery of SPIO with Lipiodol might be a good drug delivery system targeting the hepatic tumors, as confirmed by image-based analysis.https://doi.org/10.1177/1536012116689001 |
| spellingShingle | In Joon Lee MD, PhD Ji Yong Park MS Young-il Kim MD, PhD Yun-Sang Lee PhD Jae Min Jeong PhD Jaeil Kim BS Euishin Edmund Kim MD, PhD Keon Wook Kang MD, PhD Dong Soo Lee MD, PhD Seonji Jeong MD Eun Jeong Kim BS Young Il Kim MD, PhD Jin Wook Chung MD, PhD Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI Molecular Imaging |
| title | Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI |
| title_full | Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI |
| title_fullStr | Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI |
| title_full_unstemmed | Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI |
| title_short | Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI |
| title_sort | image based analysis of tumor localization after intra arterial delivery of technetium 99m labeled spio using spect ct and mri |
| url | https://doi.org/10.1177/1536012116689001 |
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