Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI

Image-Based Analysis of Tumor Localization After Intra-Arterial Delivery of Technetium-99m-Labeled SPIO Using SPECT/CT and MRI

The aim of this study is to evaluate the localization of 99m Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered 99m Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localizat...

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Main Authors: In Joon Lee MD, PhD, Ji Yong Park MS, Young-il Kim MD, PhD, Yun-Sang Lee PhD, Jae Min Jeong PhD, Jaeil Kim BS, Euishin Edmund Kim MD, PhD, Keon Wook Kang MD, PhD, Dong Soo Lee MD, PhD, Seonji Jeong MD, Eun Jeong Kim BS, Young Il Kim MD, PhD, Jin Wook Chung MD, PhD
Format: Article
Language:English
Published: SAGE Publishing 2017-01-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1177/1536012116689001
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Summary:The aim of this study is to evaluate the localization of 99m Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered 99m Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of 99m Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs. Intra-arterial delivery of SPIO with Lipiodol might be a good drug delivery system targeting the hepatic tumors, as confirmed by image-based analysis.
ISSN:1536-0121

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