The Effect Of Andaliman Fruit (Zanthoxylum Acanthopodium) Extract On Oxidative Stress In The Pancreas Of Rats (Ratus Norvegicus) Induced By D-Galactose
ABSTRACT Aging is a physiological process that causes the decline of tissues and organs in an individual. The cause of aging is believed to be due to an increase in reactive oxygen species (ROS) which are oxidative, resulting in cell membrane damage and DNA mutations. One of the organs most frequ...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Poltekkes Kemenkes Yogyakarta
2024-01-01
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| Series: | Jurnal Teknologi Laboratorium |
| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/381 |
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| Summary: | ABSTRACT
Aging is a physiological process that causes the decline of tissues and organs in an individual. The cause of aging is believed to be due to an increase in reactive oxygen species (ROS) which are oxidative, resulting in cell membrane damage and DNA mutations. One of the organs most frequently damaged is the pancreas which functions in maintaining the function of sugar in the individual's body. Damage to the pancreas causes degenerative diseases, one of which is Diabetes Mellitus, which often occurs in old age. The efforts to reduce the occurrence of ROS due to aging is to consume antioxidants. Andaliman fruit is a native plant of Sumatra which is often used as a cooking spice. This plant contains a lot of flavonoid substances that function as antioxidative, anti-inflammatory, antimutagenic and anticarcinogenic. The purpose of this study was to examine the effect of andaliman fruit extract on body weight, blood sugar levels, MDA levels, and histopathological features of the pancreas of the mice. The Research methods design is post-test only control group design .The samples used were 32 white rats which were divided into 4 groups, namely the control group and the andaliman fruit extract dose group of 100, 150, 200 milligrams per kilogram of body weight. Data analysis using One-way Analysis of Variance. The results showed that there was an effect of fruit extract on body weight, blood sugar levels, MDA levels and histopathological features of the pancreas |
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| ISSN: | 2338-5634 2580-0191 |