雷帕霉素对血管平滑肌细胞增殖影响的实验研究
【目的】观察雷帕霉素(rapamycin)对体外培养的大鼠胸主动脉平滑肌细胞(SMC)增殖的作用。【方法】组织贴块法体外原代培养大鼠胸主动脉平滑肌细胞,取对数生长期细胞(第6-10代)用作实验,MTr法检测不同浓度雷帕霉素对平滑肌细胞增殖的效果,并用RT-PCR法检测其对平滑肌细胞增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)mRNA表达情况的影响。【结果】①MTT法检测显示雷帕霉素呈剂量依赖性抑制体外培养的大鼠平滑肌细胞增殖,各组吸光值似)分别为:对照组0.902±0.106;0.1ng/mL组0.873±0.079;1ng/mL组0.797...
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Main Authors: | 王建波, 杨建勇, 陈伟, 庄文权, 张珑涓 |
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Format: | Article |
Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2006-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
Subjects: | |
Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43583339/ |
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