Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions
Abstract Indocyanine green (ICG) is a diagnostic dye commonly used in medical imaging and liver function monitoring. Given its widespread use, there is a need for detailed evaluations of its adverse drug reactions in real-world settings. As the comprehensive overview of its safety profile is very li...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-81903-z |
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| author | Yan Jiao Yahui Liu Meng Jin |
| author_facet | Yan Jiao Yahui Liu Meng Jin |
| author_sort | Yan Jiao |
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| description | Abstract Indocyanine green (ICG) is a diagnostic dye commonly used in medical imaging and liver function monitoring. Given its widespread use, there is a need for detailed evaluations of its adverse drug reactions in real-world settings. As the comprehensive overview of its safety profile is very limited, this study aimed to analyze the adverse events (AEs) associated with ICG using data from the Food and Drug Administration Adverse Event Reporting System (FAERS). Data between 2004Q1 and 2023Q4 were extracted from the FAERS database. Signal detection was performed using various disproportionality analysis algorithms, including reporting odds ratio (ROR), proportional reporting ratio, Bayesian confidence propagation neural network, and multiitem gamma Poisson shrinker. During the study period, a total of 62 ICG-related AEs were reported in the FAERS database. Significant clinical adverse reactions included anaphylactic shock (ROR: 92.10, 95% confidence interval (CI): 37.71-224.96), procedural hypotension (ROR: 1397.27, 95% CI: 443.31-4404.08), and urticaria (ROR: 10.88, 95% CI: 4.02–29.42). This study provides valuable insights into the safety profile of ICG, highlighting the need for further monitoring to ensure its safe clinical use in clinical practice. Ongoing pharmacovigilance and large-scale studies are warranted to fully understand the potential risks associated with ICG. |
| format | Article |
| id | doaj-art-2d9fae1ba3314effab9eaf989c6adce6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-2d9fae1ba3314effab9eaf989c6adce62024-12-08T12:30:42ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-81903-zExploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactionsYan Jiao0Yahui Liu1Meng Jin2Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin UniversityDepartment of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin UniversityDepartment of Radiation Oncology, Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin UniversityAbstract Indocyanine green (ICG) is a diagnostic dye commonly used in medical imaging and liver function monitoring. Given its widespread use, there is a need for detailed evaluations of its adverse drug reactions in real-world settings. As the comprehensive overview of its safety profile is very limited, this study aimed to analyze the adverse events (AEs) associated with ICG using data from the Food and Drug Administration Adverse Event Reporting System (FAERS). Data between 2004Q1 and 2023Q4 were extracted from the FAERS database. Signal detection was performed using various disproportionality analysis algorithms, including reporting odds ratio (ROR), proportional reporting ratio, Bayesian confidence propagation neural network, and multiitem gamma Poisson shrinker. During the study period, a total of 62 ICG-related AEs were reported in the FAERS database. Significant clinical adverse reactions included anaphylactic shock (ROR: 92.10, 95% confidence interval (CI): 37.71-224.96), procedural hypotension (ROR: 1397.27, 95% CI: 443.31-4404.08), and urticaria (ROR: 10.88, 95% CI: 4.02–29.42). This study provides valuable insights into the safety profile of ICG, highlighting the need for further monitoring to ensure its safe clinical use in clinical practice. Ongoing pharmacovigilance and large-scale studies are warranted to fully understand the potential risks associated with ICG.https://doi.org/10.1038/s41598-024-81903-zIndocyanine greenAdverse drug reactionsFAERS databasePharmacovigilanceSignal detection |
| spellingShingle | Yan Jiao Yahui Liu Meng Jin Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions Scientific Reports Indocyanine green Adverse drug reactions FAERS database Pharmacovigilance Signal detection |
| title | Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions |
| title_full | Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions |
| title_fullStr | Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions |
| title_full_unstemmed | Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions |
| title_short | Exploring the dark side of diagnostic dyes with a focus on Indocyanine green’s adverse reactions |
| title_sort | exploring the dark side of diagnostic dyes with a focus on indocyanine green s adverse reactions |
| topic | Indocyanine green Adverse drug reactions FAERS database Pharmacovigilance Signal detection |
| url | https://doi.org/10.1038/s41598-024-81903-z |
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