Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS)
Background: Out-of-hospital cardiac arrest (OHCA) is an emergency with historically low survival rates. Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. However, there is insufficient high-quality...
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Elsevier
2025-05-01
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| Series: | Resuscitation Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266652042500075X |
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| author | Pin Pin Pek Megan Chua Le Xuan Liew Christina Chen Shir-Lynn Lim Felix Maverick Rubillar Uy Vui Kian Ho Yew Woon Chia Jia Min Chua Ee Ling Goh Lai Peng Tham Pei Lin Koh Kai Lee Woo Cheryl Ting Zhen Woo Iylia Muhammad Afiq Kexin Fang Han Nee Gan Benjamin Sieu-Hon Leong Desmond Ren-Hao Mao Nausheen Edwin Doctor Wei Ming Ng Ying Zi Oh Kah Hua Peck Ruth Weixian Chen Michael Yih-Chong Chia Wei Ling Tay Shun Yee Low Andrew Yunkai Li Shu-Ling Chong Jia Min Kang S. Priyalatha Audrey Qing Qing Chia Nur Shahidah Benny Jun Heng Ng Kai Yi Lee Nan Luo Marcus Eng Hock Ong Andrew Fu Wah Ho |
| author_facet | Pin Pin Pek Megan Chua Le Xuan Liew Christina Chen Shir-Lynn Lim Felix Maverick Rubillar Uy Vui Kian Ho Yew Woon Chia Jia Min Chua Ee Ling Goh Lai Peng Tham Pei Lin Koh Kai Lee Woo Cheryl Ting Zhen Woo Iylia Muhammad Afiq Kexin Fang Han Nee Gan Benjamin Sieu-Hon Leong Desmond Ren-Hao Mao Nausheen Edwin Doctor Wei Ming Ng Ying Zi Oh Kah Hua Peck Ruth Weixian Chen Michael Yih-Chong Chia Wei Ling Tay Shun Yee Low Andrew Yunkai Li Shu-Ling Chong Jia Min Kang S. Priyalatha Audrey Qing Qing Chia Nur Shahidah Benny Jun Heng Ng Kai Yi Lee Nan Luo Marcus Eng Hock Ong Andrew Fu Wah Ho |
| author_sort | Pin Pin Pek |
| collection | DOAJ |
| description | Background: Out-of-hospital cardiac arrest (OHCA) is an emergency with historically low survival rates. Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. However, there is insufficient high-quality population-based long-term survivorship data and limited research on the impact of OHCA sequelae on survivors’ caregivers. Objective: Our primary aim is to determine neurological function, physical, psychological, cognitive, social outcomes, and health-related quality of life (HRQoL) of OHCA survivors in Singapore. Secondary aims are to quantify caregivers’ burden and its association with their HRQoL, and psychological well-being. Methods: The Quality Cardiac Arrest Survivorship Cohort Study (QualiCAS) is a prospective population-based cohort study of OHCA survivors and their caregivers in Singapore. Participants aged ≥18 years and caregivers aged ≥21 years will be recruited from all public hospitals in Singapore. Health outcomes will be evaluated at 3, 6, and 12 months, and 3 and 5 years using the Hospital Anxiety and Depression Scale, PTSD Checklist for DSM-5, Fatigue Severity Scale, Montreal Cognitive Assessment Tool, EQ-5D-5L, Community Integration Questionnaire-Revised, Barthel Index, Lawton’s Instrumental Activities of Daily Living, Timed Up and Go Test, Handgrip strength assessment, and Zarit Burden Interview. Discussion: This study allows us to understand the natural history of OHCA survivorship and quantify the burdens on patients and their caregivers. Findings can guide clinical follow-up, identify high-risk patients, intervention targets, and inform rehabilitation strategies for OHCA sequelae. |
| format | Article |
| id | doaj-art-2d997a03b6f54d1cb9cc7eb40815f41b |
| institution | Kabale University |
| issn | 2666-5204 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj-art-2d997a03b6f54d1cb9cc7eb40815f41b2025-08-20T03:53:53ZengElsevierResuscitation Plus2666-52042025-05-012310093810.1016/j.resplu.2025.100938Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS)Pin Pin Pek0Megan Chua1Le Xuan Liew2Christina Chen3Shir-Lynn Lim4Felix Maverick Rubillar Uy5Vui Kian Ho6Yew Woon Chia7Jia Min Chua8Ee Ling Goh9Lai Peng Tham10Pei Lin Koh11Kai Lee Woo12Cheryl Ting Zhen Woo13Iylia Muhammad Afiq14Kexin Fang15Han Nee Gan16Benjamin Sieu-Hon Leong17Desmond Ren-Hao Mao18Nausheen Edwin Doctor19Wei Ming Ng20Ying Zi Oh21Kah Hua Peck22Ruth Weixian Chen23Michael Yih-Chong Chia24Wei Ling Tay25Shun Yee Low26Andrew Yunkai Li27Shu-Ling Chong28Jia Min Kang29S. Priyalatha30Audrey Qing Qing Chia31Nur Shahidah32Benny Jun Heng Ng33Kai Yi Lee34Nan Luo35Marcus Eng Hock Ong36Andrew Fu Wah Ho37Pre-hospital & Emergency Research Centre, Duke-NUS Medical School, Singapore; Department of Emergency Medicine, Singapore General Hospital, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Emergency Medicine, Singapore General Hospital, SingaporePre-hospital & Emergency Research Centre, Duke-NUS Medical School, SingaporePre-hospital & Emergency Research Centre, Duke-NUS Medical School, Singapore; Department of Cardiology, National University Heart Centre, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Cardiology, Changi General Hospital, SingaporeDepartment of Intensive Care Medicine, Sengkang General Hospital, SingaporeCardiac Intensive Care Unit, Department of Cardiology, Tan Tock Seng Hospital, SingaporeDepartment of Cardiology, Khoo Teck Puat Hospital, SingaporeEmergency Medicine Department, Ng Teng Fong General Hospital, SingaporeChildren’s Emergency, KK Women’s and Children’s Hospital, SingaporeKhoo Teck Puat - National University Children’s Medical Institute, National University Health System, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Cardiology, National University Heart Centre, SingaporeEmergency Medicine Department, National University Hospital, SingaporeDepartment of Emergency Medicine, Singapore General Hospital, SingaporeDuke-NUS Medical School, SingaporeAccident & Emergency, Changi General Hospital, SingaporeEmergency Medicine Department, National University Hospital, SingaporeDepartment of Acute & Emergency Care, Khoo Teck Puat Hospital, SingaporeDepartment of Emergency Medicine, Sengkang General Hospital, SingaporeEmergency Medicine Department, Ng Teng Fong General Hospital, SingaporeDepartment of Cardiology, Changi General Hospital, SingaporeDepartment of Cardiology, Khoo Teck Puat Hospital, SingaporeDepartment of Cardiology, Woodlands Health, SingaporeEmergency Department, Tan Tock Seng Hospital, SingaporeEmergency Medicine Department, Ng Teng Fong General Hospital, SingaporeDepartment of Emergency Medicine, Sengkang General Hospital, SingaporeRespiratory Medicine, Department of Medicine, Woodlands Health, SingaporeChildren’s Emergency, KK Women’s and Children’s Hospital, SingaporeClinical Research & Innovation Office, Tan Tock Seng Hospital, SingaporeClinical Research Unit, Khoo Teck Puat Hospital, SingaporeKK Research Centre, KK Women’s & Children’s Hospital, SingaporePre-hospital & Emergency Research Centre, Duke-NUS Medical School, Singapore; Department of Emergency Medicine, Singapore General Hospital, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, SingaporeDepartment of Emergency Medicine, Singapore General Hospital, SingaporePre-hospital & Emergency Research Centre, Duke-NUS Medical School, Singapore; Department of Emergency Medicine, Singapore General Hospital, Singapore; Centre for Population Health Research and Implementation, SingHealth Regional Health System, Singapore; Corresponding author at: at: Singapore General Hospital, Outram Road, Singapore 169608.Background: Out-of-hospital cardiac arrest (OHCA) is an emergency with historically low survival rates. Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. However, there is insufficient high-quality population-based long-term survivorship data and limited research on the impact of OHCA sequelae on survivors’ caregivers. Objective: Our primary aim is to determine neurological function, physical, psychological, cognitive, social outcomes, and health-related quality of life (HRQoL) of OHCA survivors in Singapore. Secondary aims are to quantify caregivers’ burden and its association with their HRQoL, and psychological well-being. Methods: The Quality Cardiac Arrest Survivorship Cohort Study (QualiCAS) is a prospective population-based cohort study of OHCA survivors and their caregivers in Singapore. Participants aged ≥18 years and caregivers aged ≥21 years will be recruited from all public hospitals in Singapore. Health outcomes will be evaluated at 3, 6, and 12 months, and 3 and 5 years using the Hospital Anxiety and Depression Scale, PTSD Checklist for DSM-5, Fatigue Severity Scale, Montreal Cognitive Assessment Tool, EQ-5D-5L, Community Integration Questionnaire-Revised, Barthel Index, Lawton’s Instrumental Activities of Daily Living, Timed Up and Go Test, Handgrip strength assessment, and Zarit Burden Interview. Discussion: This study allows us to understand the natural history of OHCA survivorship and quantify the burdens on patients and their caregivers. Findings can guide clinical follow-up, identify high-risk patients, intervention targets, and inform rehabilitation strategies for OHCA sequelae.http://www.sciencedirect.com/science/article/pii/S266652042500075XCardiac ArrestSurvivorship-outcomesNeurocognitivePsychosocialCaregiverHRQoL (Health Related Quality of Life) |
| spellingShingle | Pin Pin Pek Megan Chua Le Xuan Liew Christina Chen Shir-Lynn Lim Felix Maverick Rubillar Uy Vui Kian Ho Yew Woon Chia Jia Min Chua Ee Ling Goh Lai Peng Tham Pei Lin Koh Kai Lee Woo Cheryl Ting Zhen Woo Iylia Muhammad Afiq Kexin Fang Han Nee Gan Benjamin Sieu-Hon Leong Desmond Ren-Hao Mao Nausheen Edwin Doctor Wei Ming Ng Ying Zi Oh Kah Hua Peck Ruth Weixian Chen Michael Yih-Chong Chia Wei Ling Tay Shun Yee Low Andrew Yunkai Li Shu-Ling Chong Jia Min Kang S. Priyalatha Audrey Qing Qing Chia Nur Shahidah Benny Jun Heng Ng Kai Yi Lee Nan Luo Marcus Eng Hock Ong Andrew Fu Wah Ho Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS) Resuscitation Plus Cardiac Arrest Survivorship-outcomes Neurocognitive Psychosocial Caregiver HRQoL (Health Related Quality of Life) |
| title | Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS) |
| title_full | Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS) |
| title_fullStr | Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS) |
| title_full_unstemmed | Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS) |
| title_short | Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS) |
| title_sort | physical psychological cognitive social health outcomes and health related quality of life in out of hospital cardiac arrest survivors and their caregivers protocol of the quality cardiac arrest survivorship cohort study qualicas |
| topic | Cardiac Arrest Survivorship-outcomes Neurocognitive Psychosocial Caregiver HRQoL (Health Related Quality of Life) |
| url | http://www.sciencedirect.com/science/article/pii/S266652042500075X |
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