Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS)

Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the quality cardiac arrest survivorship cohort study (QualiCAS)

Background: Out-of-hospital cardiac arrest (OHCA) is an emergency with historically low survival rates. Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. However, there is insufficient high-quality...

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Main Authors: Pin Pin Pek, Megan Chua, Le Xuan Liew, Christina Chen, Shir-Lynn Lim, Felix Maverick Rubillar Uy, Vui Kian Ho, Yew Woon Chia, Jia Min Chua, Ee Ling Goh, Lai Peng Tham, Pei Lin Koh, Kai Lee Woo, Cheryl Ting Zhen Woo, Iylia Muhammad Afiq, Kexin Fang, Han Nee Gan, Benjamin Sieu-Hon Leong, Desmond Ren-Hao Mao, Nausheen Edwin Doctor, Wei Ming Ng, Ying Zi Oh, Kah Hua Peck, Ruth Weixian Chen, Michael Yih-Chong Chia, Wei Ling Tay, Shun Yee Low, Andrew Yunkai Li, Shu-Ling Chong, Jia Min Kang, S. Priyalatha, Audrey Qing Qing Chia, Nur Shahidah, Benny Jun Heng Ng, Kai Yi Lee, Nan Luo, Marcus Eng Hock Ong, Andrew Fu Wah Ho
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Resuscitation Plus
Subjects:
Cardiac Arrest
Survivorship-outcomes
Neurocognitive
Psychosocial
Caregiver
HRQoL (Health Related Quality of Life)
Online Access:http://www.sciencedirect.com/science/article/pii/S266652042500075X
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Summary:Background: Out-of-hospital cardiac arrest (OHCA) is an emergency with historically low survival rates. Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. However, there is insufficient high-quality population-based long-term survivorship data and limited research on the impact of OHCA sequelae on survivors’ caregivers. Objective: Our primary aim is to determine neurological function, physical, psychological, cognitive, social outcomes, and health-related quality of life (HRQoL) of OHCA survivors in Singapore. Secondary aims are to quantify caregivers’ burden and its association with their HRQoL, and psychological well-being. Methods: The Quality Cardiac Arrest Survivorship Cohort Study (QualiCAS) is a prospective population-based cohort study of OHCA survivors and their caregivers in Singapore. Participants aged ≥18 years and caregivers aged ≥21 years will be recruited from all public hospitals in Singapore. Health outcomes will be evaluated at 3, 6, and 12 months, and 3 and 5 years using the Hospital Anxiety and Depression Scale, PTSD Checklist for DSM-5, Fatigue Severity Scale, Montreal Cognitive Assessment Tool, EQ-5D-5L, Community Integration Questionnaire-Revised, Barthel Index, Lawton’s Instrumental Activities of Daily Living, Timed Up and Go Test, Handgrip strength assessment, and Zarit Burden Interview. Discussion: This study allows us to understand the natural history of OHCA survivorship and quantify the burdens on patients and their caregivers. Findings can guide clinical follow-up, identify high-risk patients, intervention targets, and inform rehabilitation strategies for OHCA sequelae.
ISSN:2666-5204

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