Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement
We describe a rare case of skin-limited immunoglobulin A vasculitis (IgAV) in an adult with polycythemia vera (PV), a myeloproliferative neoplasm more commonly associated with IgA nephropathy (IgAN) than IgAV. Diagnosis was confirmed by biopsy showing IgA-dominant leukocytoclastic vasculitis without...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2025-07-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1200 |
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| _version_ | 1849318531764584448 |
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| author | Christian Cook Jiwoo Kim Escher Howard-Williams Evan Raff |
| author_facet | Christian Cook Jiwoo Kim Escher Howard-Williams Evan Raff |
| author_sort | Christian Cook |
| collection | DOAJ |
| description | We describe a rare case of skin-limited immunoglobulin A vasculitis (IgAV) in an adult with polycythemia vera (PV), a myeloproliferative neoplasm more commonly associated with IgA nephropathy (IgAN) than IgAV. Diagnosis was confirmed by biopsy showing IgA-dominant leukocytoclastic vasculitis without systemic involvement. Our patient was treated supportively for IgAV and with ruxolitinib for PV, with resolution of skin findings and no systemic progression. Although vasculitis is more commonly associated with myelodysplastic syndromes, its occurrence with PV is rare. Careful evaluation for renal involvement in IgAV is essential to guide management and to monitor for systemic progression, particularly renal manifestations. |
| format | Article |
| id | doaj-art-2d7d08e81ade4c5fbd6f2f36d828a2a3 |
| institution | Kabale University |
| issn | 2767-7664 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-2d7d08e81ade4c5fbd6f2f36d828a2a32025-08-20T03:50:48ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642025-07-014710.7326/aimcc.2024.1200Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal InvolvementChristian Cook0Jiwoo Kim1Escher Howard-Williams2Evan Raff31University of North Carolina, School of Medicine, Chapel Hill, North Carolina1University of North Carolina, School of Medicine, Chapel Hill, North Carolina1University of North Carolina, School of Medicine, Chapel Hill, North Carolina1University of North Carolina, School of Medicine, Chapel Hill, North CarolinaWe describe a rare case of skin-limited immunoglobulin A vasculitis (IgAV) in an adult with polycythemia vera (PV), a myeloproliferative neoplasm more commonly associated with IgA nephropathy (IgAN) than IgAV. Diagnosis was confirmed by biopsy showing IgA-dominant leukocytoclastic vasculitis without systemic involvement. Our patient was treated supportively for IgAV and with ruxolitinib for PV, with resolution of skin findings and no systemic progression. Although vasculitis is more commonly associated with myelodysplastic syndromes, its occurrence with PV is rare. Careful evaluation for renal involvement in IgAV is essential to guide management and to monitor for systemic progression, particularly renal manifestations.https://www.acpjournals.org/doi/10.7326/aimcc.2024.1200 |
| spellingShingle | Christian Cook Jiwoo Kim Escher Howard-Williams Evan Raff Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement Annals of Internal Medicine: Clinical Cases |
| title | Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement |
| title_full | Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement |
| title_fullStr | Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement |
| title_full_unstemmed | Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement |
| title_short | Skin-Limited IgA Vasculitis: A Unique Presentation in an Adult Without Renal Involvement |
| title_sort | skin limited iga vasculitis a unique presentation in an adult without renal involvement |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2024.1200 |
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