Secondary motor cortex tracks decision value during the learning of a non-instructed task
Summary: Optimal decision-making depends on interconnected frontal brain regions, enabling animals to adapt decisions based on internal states, experiences, and contexts. The secondary motor cortex (M2) is key in adaptive behaviors in expert rodents, particularly in encoding decision values guiding...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724015031 |
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| author | Elisabete Augusto Vladimir Kouskoff Nicolas Chenouard Margaux Giraudet Léa Peltier Aron de Miranda Alexy Louis Lucille Alonso Frédéric Gambino |
| author_facet | Elisabete Augusto Vladimir Kouskoff Nicolas Chenouard Margaux Giraudet Léa Peltier Aron de Miranda Alexy Louis Lucille Alonso Frédéric Gambino |
| author_sort | Elisabete Augusto |
| collection | DOAJ |
| description | Summary: Optimal decision-making depends on interconnected frontal brain regions, enabling animals to adapt decisions based on internal states, experiences, and contexts. The secondary motor cortex (M2) is key in adaptive behaviors in expert rodents, particularly in encoding decision values guiding complex probabilistic tasks. However, its role in deterministic tasks during initial learning remains uncertain. Here, we describe a self-initiated deterministic task requiring mice to use their forepaws to make choices without guiding cues. Our findings reveal that spontaneous decisions follow a “race” model between actions, which uncovers underlying decision values. We use in vivo microscopy and modeling to show that M2 neurons in male mice exhibit persistent activity-encoding decision values that predict action-selection probabilities. Optogenetic inhibition of the M2 reduces the reversal performance and alters the decision value. Additionally, updates in decision values determine the rate at which learning is reversed. These results highlight the use of decision values by the M2 to adapt choice during initial learning without instructive cues. |
| format | Article |
| id | doaj-art-2d771dec9c884f78a482d7e7f7eaeb76 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-2d771dec9c884f78a482d7e7f7eaeb762025-01-07T04:17:19ZengElsevierCell Reports2211-12472025-01-01441115152Secondary motor cortex tracks decision value during the learning of a non-instructed taskElisabete Augusto0Vladimir Kouskoff1Nicolas Chenouard2Margaux Giraudet3Léa Peltier4Aron de Miranda5Alexy Louis6Lucille Alonso7Frédéric Gambino8Institut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, FranceInstitut Interdisciplinaire de Neurosciences (IINS), University Bordeaux, CNRS, IINS, UMR 5297, 33000 Bordeaux, France; Centre Broca Nouvelle-Aquitaine, 146, rue Léo-Saignat, 33076 Bordeaux, France; Corresponding authorSummary: Optimal decision-making depends on interconnected frontal brain regions, enabling animals to adapt decisions based on internal states, experiences, and contexts. The secondary motor cortex (M2) is key in adaptive behaviors in expert rodents, particularly in encoding decision values guiding complex probabilistic tasks. However, its role in deterministic tasks during initial learning remains uncertain. Here, we describe a self-initiated deterministic task requiring mice to use their forepaws to make choices without guiding cues. Our findings reveal that spontaneous decisions follow a “race” model between actions, which uncovers underlying decision values. We use in vivo microscopy and modeling to show that M2 neurons in male mice exhibit persistent activity-encoding decision values that predict action-selection probabilities. Optogenetic inhibition of the M2 reduces the reversal performance and alters the decision value. Additionally, updates in decision values determine the rate at which learning is reversed. These results highlight the use of decision values by the M2 to adapt choice during initial learning without instructive cues.http://www.sciencedirect.com/science/article/pii/S2211124724015031CP: Neuroscience |
| spellingShingle | Elisabete Augusto Vladimir Kouskoff Nicolas Chenouard Margaux Giraudet Léa Peltier Aron de Miranda Alexy Louis Lucille Alonso Frédéric Gambino Secondary motor cortex tracks decision value during the learning of a non-instructed task Cell Reports CP: Neuroscience |
| title | Secondary motor cortex tracks decision value during the learning of a non-instructed task |
| title_full | Secondary motor cortex tracks decision value during the learning of a non-instructed task |
| title_fullStr | Secondary motor cortex tracks decision value during the learning of a non-instructed task |
| title_full_unstemmed | Secondary motor cortex tracks decision value during the learning of a non-instructed task |
| title_short | Secondary motor cortex tracks decision value during the learning of a non-instructed task |
| title_sort | secondary motor cortex tracks decision value during the learning of a non instructed task |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724015031 |
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