Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity.

Patterns and functional consequences of antibody speciation in maternal-fetal transfer of coronavirus-specific humoral immunity.

Maternal antibodies serve as a temporary form of inherited immunity, providing humoral protection to vulnerable neonates. Whereas IgG is actively transferred up a concentration gradient via the neonatal Fc Receptor (FcRn), maternal IgA and IgM are typically excluded from fetal circulation. Further,...

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Main Authors: Andrew P Hederman, Hannah M Brookes, Harini Natarajan, Leo Heyndrickx, Kevin K Ariën, Joshua A Weiner, Amihai Rottenstreich, Gila Zarbiv, Dana Wolf, Tessa Goetghebuer, Arnaud Marchant, Margaret E Ackerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013408
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