Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression
The mitochondria are highly plastic organelles. Exercise training alters mitochondrial dynamics (mitochondrial fission and fusion) in skeletal muscles and improves overall mitochondrial function by altering mitochondrial morphology and forming new networks. However, changes in mitochondrial dynamics...
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Japanese Society of Physical Fitness and Sports Medicine
2025-01-01
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| Series: | Journal of Physical Fitness and Sports Medicine |
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| Online Access: | https://www.jstage.jst.go.jp/article/jpfsm/14/1/14_9/_pdf/-char/en |
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| author | Hisashi Takakura Hitomi Banba Tatsuya Yamada Rikuhide Koma Tsubasa Shibaguchi Yudai Nonaka Kazumi Masuda |
| author_facet | Hisashi Takakura Hitomi Banba Tatsuya Yamada Rikuhide Koma Tsubasa Shibaguchi Yudai Nonaka Kazumi Masuda |
| author_sort | Hisashi Takakura |
| collection | DOAJ |
| description | The mitochondria are highly plastic organelles. Exercise training alters mitochondrial dynamics (mitochondrial fission and fusion) in skeletal muscles and improves overall mitochondrial function by altering mitochondrial morphology and forming new networks. However, changes in mitochondrial dynamics over time during exercise training have not previously been observed. In the present study, we examined the changes in mitochondrial fission and fusion protein expression in rats over four weeks of endurance swimming training. The expression of the GTPase protein dynamin-related protein 1 (Drp1), a mitochondrial fission protein, increased during the early phase of the training period. In contrast, the expression of optic atrophy type 1 (OPA1), a mitochondrial fusion protein, was increased in the late phase of the training period. These data suggest that mitochondrial fission was increased in the early phase, and mitochondrial fusion was initiated partially in the late phase, of the training period. In conclusion, mitochondrial dynamics may be modulated depending on the phase of muscular adaptation to exercise training. This modulation contributes to enhanced mitochondrial function in skeletal muscle. |
| format | Article |
| id | doaj-art-2d2330694a4e43519d835adf2a6ebc39 |
| institution | Kabale University |
| issn | 2186-8131 2186-8123 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Japanese Society of Physical Fitness and Sports Medicine |
| record_format | Article |
| series | Journal of Physical Fitness and Sports Medicine |
| spelling | doaj-art-2d2330694a4e43519d835adf2a6ebc392025-01-14T01:48:15ZengJapanese Society of Physical Fitness and Sports MedicineJournal of Physical Fitness and Sports Medicine2186-81312186-81232025-01-0114191710.7600/jpfsm.14.9jpfsmModulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expressionHisashi Takakura0Hitomi Banba1Tatsuya Yamada2Rikuhide Koma3Tsubasa Shibaguchi4Yudai Nonaka5Kazumi Masuda6Faculty of Health and Sports Science, Doshisha UniversityFaculty of Human Sciences, Kanazawa UniversityDepartment of Biochemistry, University of Nebraska-LincolnFaculty of Human Sciences, Kanazawa UniversityInstitute of Liberal Arts and Science, Kanazawa UniversityInstitute of Liberal Arts and Science, Kanazawa UniversityFaculty of Human Sciences, Kanazawa UniversityThe mitochondria are highly plastic organelles. Exercise training alters mitochondrial dynamics (mitochondrial fission and fusion) in skeletal muscles and improves overall mitochondrial function by altering mitochondrial morphology and forming new networks. However, changes in mitochondrial dynamics over time during exercise training have not previously been observed. In the present study, we examined the changes in mitochondrial fission and fusion protein expression in rats over four weeks of endurance swimming training. The expression of the GTPase protein dynamin-related protein 1 (Drp1), a mitochondrial fission protein, increased during the early phase of the training period. In contrast, the expression of optic atrophy type 1 (OPA1), a mitochondrial fusion protein, was increased in the late phase of the training period. These data suggest that mitochondrial fission was increased in the early phase, and mitochondrial fusion was initiated partially in the late phase, of the training period. In conclusion, mitochondrial dynamics may be modulated depending on the phase of muscular adaptation to exercise training. This modulation contributes to enhanced mitochondrial function in skeletal muscle.https://www.jstage.jst.go.jp/article/jpfsm/14/1/14_9/_pdf/-char/enendurance trainingmitochondrial fusion and fissionprotein expressionskeletal muscle |
| spellingShingle | Hisashi Takakura Hitomi Banba Tatsuya Yamada Rikuhide Koma Tsubasa Shibaguchi Yudai Nonaka Kazumi Masuda Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression Journal of Physical Fitness and Sports Medicine endurance training mitochondrial fusion and fission protein expression skeletal muscle |
| title | Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression |
| title_full | Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression |
| title_fullStr | Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression |
| title_full_unstemmed | Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression |
| title_short | Modulation of mitochondrial dynamics in skeletal muscle during endurance training: early activation of fission and late induction of fusion protein expression |
| title_sort | modulation of mitochondrial dynamics in skeletal muscle during endurance training early activation of fission and late induction of fusion protein expression |
| topic | endurance training mitochondrial fusion and fission protein expression skeletal muscle |
| url | https://www.jstage.jst.go.jp/article/jpfsm/14/1/14_9/_pdf/-char/en |
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