A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis
ObjectivesThe study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).MethodsVarious databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies p...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1461754/full |
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| author | Jianyu Chen Jianyu Chen Jisu Xue Jiahui Chen Jiahui Chen Tingfei Xie Tingfei Xie Xiaolu Sui Xiaolu Sui Yanzi Zhang Yanzi Zhang Aisha Zhang Aisha Zhang Yunpeng Xu Yunpeng Xu Jihong Chen Jihong Chen |
| author_facet | Jianyu Chen Jianyu Chen Jisu Xue Jiahui Chen Jiahui Chen Tingfei Xie Tingfei Xie Xiaolu Sui Xiaolu Sui Yanzi Zhang Yanzi Zhang Aisha Zhang Aisha Zhang Yunpeng Xu Yunpeng Xu Jihong Chen Jihong Chen |
| author_sort | Jianyu Chen |
| collection | DOAJ |
| description | ObjectivesThe study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).MethodsVarious databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.3 and Stata 15.1.ResultsThe analysis of 4 randomized controlled trials involving 13,943 participants found that finerenone treatment significantly decreased the urine albumin-to-creatinine ratio compared to placebo. Additionally, the risk of COVID-19, cardiovascular events, and estimated glomerular filtration rate(eGFR) reduction of at least 40% were all significantly lower in the finerenone treatment group. However, the finerenone group did experience higher baseline increases in serum potassium levels. The meta-analysis revealed that there was no variation in the likelihood of general negative outcomes (RR 1.00, 95% CI 0.98, 1.01, I2 = 0%) and the occurrence of cancers (RR 0.99, 95% CI 0.83, 1.18,I2 = 0%) among the two categories.ConclusionOur study demonstrates that finerenone has the potential to lower the chances of end-stage kidney disease, renal failure and cardiovascular mortality in individuals with diabetic kidney disease. It is important to monitor for hyperkalemia risk. The administration of finelidone among individuals with diabetic kidney disease may potentially mitigate the susceptibility to contracting COVID-19.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024536612. |
| format | Article |
| id | doaj-art-2d11d5d10be84cedabd6c5c6048c7ab5 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-2d11d5d10be84cedabd6c5c6048c7ab52024-12-20T05:10:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14617541461754A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysisJianyu Chen0Jianyu Chen1Jisu Xue2Jiahui Chen3Jiahui Chen4Tingfei Xie5Tingfei Xie6Xiaolu Sui7Xiaolu Sui8Yanzi Zhang9Yanzi Zhang10Aisha Zhang11Aisha Zhang12Yunpeng Xu13Yunpeng Xu14Jihong Chen15Jihong Chen16Department of Nephrology, The Second People’s Hospital of Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Endocrinology,The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaDepartment of Nephrology, Affiliated Bao’an Hospital of Shenzhen, The Second School of Clinical Medicine, Southern Medical University, Shenzhen, ChinaDepartment of Nephrology, The People’s Hospital of Baoan Shenzhen, Shenzhen, ChinaObjectivesThe study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).MethodsVarious databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.3 and Stata 15.1.ResultsThe analysis of 4 randomized controlled trials involving 13,943 participants found that finerenone treatment significantly decreased the urine albumin-to-creatinine ratio compared to placebo. Additionally, the risk of COVID-19, cardiovascular events, and estimated glomerular filtration rate(eGFR) reduction of at least 40% were all significantly lower in the finerenone treatment group. However, the finerenone group did experience higher baseline increases in serum potassium levels. The meta-analysis revealed that there was no variation in the likelihood of general negative outcomes (RR 1.00, 95% CI 0.98, 1.01, I2 = 0%) and the occurrence of cancers (RR 0.99, 95% CI 0.83, 1.18,I2 = 0%) among the two categories.ConclusionOur study demonstrates that finerenone has the potential to lower the chances of end-stage kidney disease, renal failure and cardiovascular mortality in individuals with diabetic kidney disease. It is important to monitor for hyperkalemia risk. The administration of finelidone among individuals with diabetic kidney disease may potentially mitigate the susceptibility to contracting COVID-19.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024536612.https://www.frontiersin.org/articles/10.3389/fendo.2024.1461754/fulldiabetic kidney diseaserenal functionCOVID-19malignancyfinerenonemeta-analysis |
| spellingShingle | Jianyu Chen Jianyu Chen Jisu Xue Jiahui Chen Jiahui Chen Tingfei Xie Tingfei Xie Xiaolu Sui Xiaolu Sui Yanzi Zhang Yanzi Zhang Aisha Zhang Aisha Zhang Yunpeng Xu Yunpeng Xu Jihong Chen Jihong Chen A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis Frontiers in Endocrinology diabetic kidney disease renal function COVID-19 malignancy finerenone meta-analysis |
| title | A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis |
| title_full | A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis |
| title_fullStr | A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis |
| title_full_unstemmed | A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis |
| title_short | A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis |
| title_sort | comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease a systematic review and meta analysis |
| topic | diabetic kidney disease renal function COVID-19 malignancy finerenone meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1461754/full |
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