Discovery of natural compounds as novel FMS-like tyrosine kinase-3 (FLT3) therapeutic inhibitors for the treatment of acute myeloid leukemia: An in-silico approach

Discovery of natural compounds as novel FMS-like tyrosine kinase-3 (FLT3) therapeutic inhibitors for the treatment of acute myeloid leukemia: An in-silico approach

FLT3 mutations, observed in approximately 30–35% of Acute Myeloid Leukemia (AML) cases, drive leukemic proliferation and survival pathways, presenting a significant challenge in clinical management. To address this therapeutic need, we employed a comprehensive computational approach integrating phar...

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Bibliographic Details
Main Authors: Uddalak Das, Lavanya Chandramouli, Akshay Uttarkar, Jitendra Kumar, Vidya Niranjan
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Aspects of Molecular Medicine
Subjects:
Acute myeloid leukemia
FLT3
Pharmacophore
Molecular docking
ADMET
Molecular dynamic simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S294968882400025X
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