IL-33/ST2 drives inflammatory pain via CCL2 signaling and activation of TRPV1 and TRPM8

IL-33/ST2 drives inflammatory pain via CCL2 signaling and activation of TRPV1 and TRPM8

Abstract Innate immunity is the first line of host defense and contributes to pain. However, how innate immune system interacts with sensory neurons to govern pain remains poorly understood. Here, we report that interleukin 33(IL-33) initiates pain hypersensitivity that requires chemokine (C-C motif...

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Main Authors: Linjie Wang, Jingyun Zhang, Shijuan Qiu, Ruizhen Huang, Yuge Wang, Yuting Wang, Mingyu Li, Qingqing Ye, Sibo Zhang, Zhenhua Qi, Lan Cao, Guohao Li, Yajie An, Denghui Xie, Wenli Mi, Huaqiao Wang, Tao Luo, Jingdun Xie, Junting Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08119-3
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https://doi.org/10.1038/s42003-025-08119-3

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