miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes, immune dysregulation, and abnormal epidermal differentiation. Its pathogenesis involves complex interactions among keratinocytes, fibroblasts, T cells, and myeloid cells, where dynamic cytoskeleta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1608902/full |
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| author | Sijing Li Sijing Li Zamri Chik Farid Nazer Faruqu Najihah Mohd Hashim Nor Saadah Mohd Yusof Jennifer Fernandez Alarcon Noraini Ahmad |
| author_facet | Sijing Li Sijing Li Zamri Chik Farid Nazer Faruqu Najihah Mohd Hashim Nor Saadah Mohd Yusof Jennifer Fernandez Alarcon Noraini Ahmad |
| author_sort | Sijing Li |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes, immune dysregulation, and abnormal epidermal differentiation. Its pathogenesis involves complex interactions among keratinocytes, fibroblasts, T cells, and myeloid cells, where dynamic cytoskeletal and extracellular matrix changes critically mediate intercellular communication. Emerging evidence highlights the pivotal roles of miRNAs and exosomes in coordinating these processes: miRNAs regulate cytoskeletal organization and extracellular matrix composition, while exosomes act as intercellular messengers that deliver miRNA-mediated signals, collectively shaping cell behavior and disease progression. This review synthesizes current knowledge on how miRNA-exosome networks drive cytoskeleton-extracellular matrix crosstalk in psoriasis, emphasizing their implications for cellular communication and tissue remodeling. By elucidating these mechanisms, we identify potential therapeutic opportunities to target pathogenic signaling pathways, offering new strategies for psoriasis management. |
| format | Article |
| id | doaj-art-2cd6f8beab5443cd950c41d4d7730f91 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-2cd6f8beab5443cd950c41d4d7730f912025-08-20T03:45:14ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-07-011310.3389/fcell.2025.16089021608902miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodelingSijing Li0Sijing Li1Zamri Chik2Farid Nazer Faruqu3Najihah Mohd Hashim4Nor Saadah Mohd Yusof5Jennifer Fernandez Alarcon6Noraini Ahmad7Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Biomedical Engineering, School of Engineering, Dali University, Dali, Yunnan, ChinaUniversiti Malaya Research Centre for Biopharmaceuticals and Advanced Therapeutics (UBAT), Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaUniversiti Malaya Research Centre for Biopharmaceuticals and Advanced Therapeutics (UBAT), Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, MalaysiaGrup d'Enginyeria de Materials (Gemat), Institut Químic de Sarrià (IQS), Universitat Ramon Llull (URL), Barcelona, SpainDepartment of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, MalaysiaPsoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes, immune dysregulation, and abnormal epidermal differentiation. Its pathogenesis involves complex interactions among keratinocytes, fibroblasts, T cells, and myeloid cells, where dynamic cytoskeletal and extracellular matrix changes critically mediate intercellular communication. Emerging evidence highlights the pivotal roles of miRNAs and exosomes in coordinating these processes: miRNAs regulate cytoskeletal organization and extracellular matrix composition, while exosomes act as intercellular messengers that deliver miRNA-mediated signals, collectively shaping cell behavior and disease progression. This review synthesizes current knowledge on how miRNA-exosome networks drive cytoskeleton-extracellular matrix crosstalk in psoriasis, emphasizing their implications for cellular communication and tissue remodeling. By elucidating these mechanisms, we identify potential therapeutic opportunities to target pathogenic signaling pathways, offering new strategies for psoriasis management.https://www.frontiersin.org/articles/10.3389/fcell.2025.1608902/fullpsoriasismiRNAexosomecytoskeletonextracellular matrix |
| spellingShingle | Sijing Li Sijing Li Zamri Chik Farid Nazer Faruqu Najihah Mohd Hashim Nor Saadah Mohd Yusof Jennifer Fernandez Alarcon Noraini Ahmad miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling Frontiers in Cell and Developmental Biology psoriasis miRNA exosome cytoskeleton extracellular matrix |
| title | miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling |
| title_full | miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling |
| title_fullStr | miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling |
| title_full_unstemmed | miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling |
| title_short | miRNAs and exosomes in psoriasis: coordinating cytoskeleton dynamics and extracellular matrix remodeling |
| title_sort | mirnas and exosomes in psoriasis coordinating cytoskeleton dynamics and extracellular matrix remodeling |
| topic | psoriasis miRNA exosome cytoskeleton extracellular matrix |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1608902/full |
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