The molecular mechanisms of cuproptosis and its relevance to atherosclerosis
Atherosclerosis is a chronic inflammatory disease associated with lipid deposition in the vascular intima. Copper is a vital trace element implicated in the onset and progression of atherosclerosis. Excessive intracellular copper accumulation induces a unique form of cell death termed “cuproptosis...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-01-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11826 |
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| author | Jiankang Wang Zhian Chen Hang Shang Jiajuan Guo |
| author_facet | Jiankang Wang Zhian Chen Hang Shang Jiajuan Guo |
| author_sort | Jiankang Wang |
| collection | DOAJ |
| description |
Atherosclerosis is a chronic inflammatory disease associated with lipid deposition in the vascular intima. Copper is a vital trace element implicated in the onset and progression of atherosclerosis. Excessive intracellular copper accumulation induces a unique form of cell death termed “cuproptosis.” The emergence of the concept of cuproptosis has highlighted the potential role of copper in atherosclerosis. This review explores the regulatory mechanisms of copper metabolism and cuproptosis, summarizes recent findings on the link between copper excess and atherosclerosis, and examines how cuproptosis may influence atherosclerosis progression. The goal is to propose novel diagnostic and therapeutic strategies for atherosclerosis through the lens of cuproptosis.
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| format | Article |
| id | doaj-art-2ca922aba7d441d6b129aa84e530cf18 |
| institution | Kabale University |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-2ca922aba7d441d6b129aa84e530cf182025-01-16T16:40:11ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-01-0110.17305/bb.2024.11826The molecular mechanisms of cuproptosis and its relevance to atherosclerosisJiankang Wang0https://orcid.org/0009-0002-9689-2324Zhian Chen1https://orcid.org/0009-0005-9756-2716Hang Shang2https://orcid.org/0009-0003-0420-5273Jiajuan Guo3https://orcid.org/0009-0009-4207-4431College of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, ChinaCollege of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, ChinaCollege of Traditional Chinese Medicine, Changchun University of Traditional Chinese Medicine, Changchun, ChinaDepartment of Cardiovascular Medicine, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China Atherosclerosis is a chronic inflammatory disease associated with lipid deposition in the vascular intima. Copper is a vital trace element implicated in the onset and progression of atherosclerosis. Excessive intracellular copper accumulation induces a unique form of cell death termed “cuproptosis.” The emergence of the concept of cuproptosis has highlighted the potential role of copper in atherosclerosis. This review explores the regulatory mechanisms of copper metabolism and cuproptosis, summarizes recent findings on the link between copper excess and atherosclerosis, and examines how cuproptosis may influence atherosclerosis progression. The goal is to propose novel diagnostic and therapeutic strategies for atherosclerosis through the lens of cuproptosis. https://www.bjbms.org/ojs/index.php/bjbms/article/view/11826CuproptosisatherosclerosisAScoppertricarboxylic acid cycleTCA cycle |
| spellingShingle | Jiankang Wang Zhian Chen Hang Shang Jiajuan Guo The molecular mechanisms of cuproptosis and its relevance to atherosclerosis Biomolecules & Biomedicine Cuproptosis atherosclerosis AS copper tricarboxylic acid cycle TCA cycle |
| title | The molecular mechanisms of cuproptosis and its relevance to atherosclerosis |
| title_full | The molecular mechanisms of cuproptosis and its relevance to atherosclerosis |
| title_fullStr | The molecular mechanisms of cuproptosis and its relevance to atherosclerosis |
| title_full_unstemmed | The molecular mechanisms of cuproptosis and its relevance to atherosclerosis |
| title_short | The molecular mechanisms of cuproptosis and its relevance to atherosclerosis |
| title_sort | molecular mechanisms of cuproptosis and its relevance to atherosclerosis |
| topic | Cuproptosis atherosclerosis AS copper tricarboxylic acid cycle TCA cycle |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11826 |
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