Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children
Purpose: To determine the homocysteine content in children and adolescents with different levels of physical activity, to establish the relationship between homocysteine content, indicators of physical development, level of physical activity and tolerance to physical activity in adolescence. Mat...
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| Format: | Article |
| Language: | English |
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Kharkiv State Academy of Physical Culture
2024-07-01
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| Series: | Фізична реабілітація та рекреаційно-оздоровчі технології |
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| Online Access: | https://phrir.com/journal/article/view/158 |
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| author | Nataliia Shliakhova Larysa Rak Vitalii Muzhanovskiy |
| author_facet | Nataliia Shliakhova Larysa Rak Vitalii Muzhanovskiy |
| author_sort | Nataliia Shliakhova |
| collection | DOAJ |
| description | Purpose: To determine the homocysteine content in children and adolescents with different levels of physical activity, to establish the relationship between homocysteine content, indicators of physical development, level of physical activity and tolerance to physical activity in adolescence.
Material and Methods. We examined 83 children aged 11 to 17 years, who were examined by a pediatrician, an endocrinologist, and the girls by a pediatric gynecologist. The study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the Committee on Bioethics and Deontology. Height, body weight and body mass index were assessed; physical activity tolerance by the Ruffier test; physical activity was assessed using a questionnaire; serum homocysteine was determined by enzyme-linked immunosorbent assay.
Results. 81% of adolescents with high physical activity had regular sports training at least three times a week. In the group with low physical fitness, only 25.6 % attended sports sections, and 44.2 % of adolescents were completely physically inactive. The level of homocysteine in the blood did not depend on the sex of adolescents and physical development. Moderate hyperhomocysteinemia was detected in 41 adolescents, 68.3 % of whom had poor and low exercise tolerance and/or low physical activity. Statistically significantly higher homocysteine levels were observed in children with low physical activity (p<0.05), those who did not have sports training (p=0.027) or had reduced adaptation to physical activity (p<0.01).
Conclusions. The level of homocysteine in the blood serum of adolescents did not depend on gender, physical development and the presence of somatic pathology. Low physical activity of adolescents is accompanied by increased levels of homocysteine in the blood. On the contrary, adolescents with high physical activity have lower levels. The lowest levels of homocysteine are observed in adolescents with good to excellent exercise tolerance. Unsatisfactory and weak Ruffier test results are associated with elevated homocysteine levels in adolescents |
| format | Article |
| id | doaj-art-2c9404c4b5584ffc80082fca6fe33bd2 |
| institution | Kabale University |
| issn | 2522-1906 2522-1914 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Kharkiv State Academy of Physical Culture |
| record_format | Article |
| series | Фізична реабілітація та рекреаційно-оздоровчі технології |
| spelling | doaj-art-2c9404c4b5584ffc80082fca6fe33bd22024-12-03T03:47:07ZengKharkiv State Academy of Physical CultureФізична реабілітація та рекреаційно-оздоровчі технології2522-19062522-19142024-07-019426928410.15391/prrht.2024-9(4).07Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent childrenNataliia Shliakhova0https://orcid.org/0000-0003-2126-2184Larysa Rak1https://orcid.org/0000-0001-9955-2638Vitalii Muzhanovskiy2https://orcid.org/0000-0001-5430-1368Department of Physical Culture and Sports Rehabilitation, Kharkiv State Academy of Physical Culture, Kharkiv, UkraineHead of the Department of Pediatrics and Rehabilitation, State Institution “Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine”, (SI “ICAHC NAMS”), Kharkiv, UkraineDepartment of Pediatrics and Rehabilitation, State Institution “Institute for Children and Adolescents Health Care at the National Academy of Medical Sciences of Ukraine”, (SI "ICAHC NAMS"), Kharkiv, UkrainePurpose: To determine the homocysteine content in children and adolescents with different levels of physical activity, to establish the relationship between homocysteine content, indicators of physical development, level of physical activity and tolerance to physical activity in adolescence. Material and Methods. We examined 83 children aged 11 to 17 years, who were examined by a pediatrician, an endocrinologist, and the girls by a pediatric gynecologist. The study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the Committee on Bioethics and Deontology. Height, body weight and body mass index were assessed; physical activity tolerance by the Ruffier test; physical activity was assessed using a questionnaire; serum homocysteine was determined by enzyme-linked immunosorbent assay. Results. 81% of adolescents with high physical activity had regular sports training at least three times a week. In the group with low physical fitness, only 25.6 % attended sports sections, and 44.2 % of adolescents were completely physically inactive. The level of homocysteine in the blood did not depend on the sex of adolescents and physical development. Moderate hyperhomocysteinemia was detected in 41 adolescents, 68.3 % of whom had poor and low exercise tolerance and/or low physical activity. Statistically significantly higher homocysteine levels were observed in children with low physical activity (p<0.05), those who did not have sports training (p=0.027) or had reduced adaptation to physical activity (p<0.01). Conclusions. The level of homocysteine in the blood serum of adolescents did not depend on gender, physical development and the presence of somatic pathology. Low physical activity of adolescents is accompanied by increased levels of homocysteine in the blood. On the contrary, adolescents with high physical activity have lower levels. The lowest levels of homocysteine are observed in adolescents with good to excellent exercise tolerance. Unsatisfactory and weak Ruffier test results are associated with elevated homocysteine levels in adolescentshttps://phrir.com/journal/article/view/158homocysteinephysical activitychildrenadolescentsexercise tolerancesport |
| spellingShingle | Nataliia Shliakhova Larysa Rak Vitalii Muzhanovskiy Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children Фізична реабілітація та рекреаційно-оздоровчі технології homocysteine physical activity children adolescents exercise tolerance sport |
| title | Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children |
| title_full | Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children |
| title_fullStr | Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children |
| title_full_unstemmed | Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children |
| title_short | Homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children |
| title_sort | homocysteine as a biomarker of physical activity and exercise tolerance in adolescent children |
| topic | homocysteine physical activity children adolescents exercise tolerance sport |
| url | https://phrir.com/journal/article/view/158 |
| work_keys_str_mv | AT nataliiashliakhova homocysteineasabiomarkerofphysicalactivityandexercisetoleranceinadolescentchildren AT larysarak homocysteineasabiomarkerofphysicalactivityandexercisetoleranceinadolescentchildren AT vitaliimuzhanovskiy homocysteineasabiomarkerofphysicalactivityandexercisetoleranceinadolescentchildren |