Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report
Abstract Background Bone infections such as chronic fungal erosive osteomyelitis are uncommon forms of bone infection. The endemic dimorphic fungus Coccidioides impact generally immunocompromised patients. These infections frequently have no symptoms and the clinical signs remain undetected, allowin...
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2025-01-01
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| Series: | Bulletin of the National Research Centre |
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| Online Access: | https://doi.org/10.1186/s42269-024-01297-w |
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| author | Paolo La Montanara Annamaria Albergo Loredana Capozzi Roberto Castellana Gerardo Cazzato Carmela De Carlo Sofia Denicolò Antonella Netti Mariacristina Poliseno Enrica Maddalena Ranieri Caterina Romano Annalisa Rossiello Stefania Stolfa Alessandra Tripoli Giuseppe Vella |
| author_facet | Paolo La Montanara Annamaria Albergo Loredana Capozzi Roberto Castellana Gerardo Cazzato Carmela De Carlo Sofia Denicolò Antonella Netti Mariacristina Poliseno Enrica Maddalena Ranieri Caterina Romano Annalisa Rossiello Stefania Stolfa Alessandra Tripoli Giuseppe Vella |
| author_sort | Paolo La Montanara |
| collection | DOAJ |
| description | Abstract Background Bone infections such as chronic fungal erosive osteomyelitis are uncommon forms of bone infection. The endemic dimorphic fungus Coccidioides impact generally immunocompromised patients. These infections frequently have no symptoms and the clinical signs remain undetected, allowing the infection to worsen over weeks or months. Mycotic arthritis is one of the rarest clinical symptoms; it is hard to distinguish from other types of arthritis, which slows down the diagnosis procedure. Case presentation In order to demonstrate the beginning and progression of radiological abnormalities in a case of aggressive fungal osteomyelitis, we provide the case of a 31-year-old male patient here. The man showed signs of extensive bone erosion and inflammatory involvement in his right knee and right hallux phalanx, although he had no prior history of immunodeficiency. The infection resulting from Coccidioides Immitis in his right knee and in his hallux was the reason for the injuries. Conclusions While an acute, benign, and self-eradicating lung infection is the predominant presentation for most cases of coccidioidomycosis, a small percentage of patients experience a devastating extrapulmonary condition, which can include arthritis. The pathogenic mechanism of bone involvement is unknown, and it often remains untreated. Here, we discuss radiographic evidence of particular bone inflammation during the early phase and later phases of the disease, since management of this chronic condition remains a challenge. We propose that imaging may mimic osseous neoplasia in persistent fungal diseases, such as coccidioidomycosis. |
| format | Article |
| id | doaj-art-2c8fc36950c54f8ab4ef26dc17bbefd8 |
| institution | Kabale University |
| issn | 2522-8307 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj-art-2c8fc36950c54f8ab4ef26dc17bbefd82025-01-12T12:07:08ZengSpringerOpenBulletin of the National Research Centre2522-83072025-01-0149111110.1186/s42269-024-01297-wEvolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case reportPaolo La Montanara0Annamaria Albergo1Loredana Capozzi2Roberto Castellana3Gerardo Cazzato4Carmela De Carlo5Sofia Denicolò6Antonella Netti7Mariacristina Poliseno8Enrica Maddalena Ranieri9Caterina Romano10Annalisa Rossiello11Stefania Stolfa12Alessandra Tripoli13Giuseppe Vella14Department of Radiology, UOSVD, DSS12 Conversano, ASL BariDepartment of Radiology, UOSVD, DSS12 Conversano, ASL BariDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”Department of Radiology, UOSVD, DSS12 Conversano, ASL BariSection of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari “Aldo Moro”U.O.C. Microbiology and Virology, University Hospital Polyclinic of Bari: Azienda Ospedaliero-Universitaria Policlinico Di BariDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”U.O.S.V.D. Nephrology and Dialysis, S. Maria Degli Angeli Hospital, ASL BariClinic of Infectious Diseases, Department of Precision Medicine and Jonian Area (DiMePreJ) Hospital, University Hospital Polyclinic of BariDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”Department of Radiology, UOSVD, DSS12 Conversano, ASL BariDepartment of Radiology, UOSVD, DSS12 Conversano, ASL BariU.O.C. Microbiology and Virology, University Hospital Polyclinic of Bari: Azienda Ospedaliero-Universitaria Policlinico Di BariGVM-Anthea HospitalDepartment of Radiology, UOSVD, DSS12 Conversano, ASL BariAbstract Background Bone infections such as chronic fungal erosive osteomyelitis are uncommon forms of bone infection. The endemic dimorphic fungus Coccidioides impact generally immunocompromised patients. These infections frequently have no symptoms and the clinical signs remain undetected, allowing the infection to worsen over weeks or months. Mycotic arthritis is one of the rarest clinical symptoms; it is hard to distinguish from other types of arthritis, which slows down the diagnosis procedure. Case presentation In order to demonstrate the beginning and progression of radiological abnormalities in a case of aggressive fungal osteomyelitis, we provide the case of a 31-year-old male patient here. The man showed signs of extensive bone erosion and inflammatory involvement in his right knee and right hallux phalanx, although he had no prior history of immunodeficiency. The infection resulting from Coccidioides Immitis in his right knee and in his hallux was the reason for the injuries. Conclusions While an acute, benign, and self-eradicating lung infection is the predominant presentation for most cases of coccidioidomycosis, a small percentage of patients experience a devastating extrapulmonary condition, which can include arthritis. The pathogenic mechanism of bone involvement is unknown, and it often remains untreated. Here, we discuss radiographic evidence of particular bone inflammation during the early phase and later phases of the disease, since management of this chronic condition remains a challenge. We propose that imaging may mimic osseous neoplasia in persistent fungal diseases, such as coccidioidomycosis.https://doi.org/10.1186/s42269-024-01297-wCoccidioidomycosisOsteomyelitisSynovitisJoint effusionBone erosionFungal |
| spellingShingle | Paolo La Montanara Annamaria Albergo Loredana Capozzi Roberto Castellana Gerardo Cazzato Carmela De Carlo Sofia Denicolò Antonella Netti Mariacristina Poliseno Enrica Maddalena Ranieri Caterina Romano Annalisa Rossiello Stefania Stolfa Alessandra Tripoli Giuseppe Vella Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report Bulletin of the National Research Centre Coccidioidomycosis Osteomyelitis Synovitis Joint effusion Bone erosion Fungal |
| title | Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report |
| title_full | Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report |
| title_fullStr | Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report |
| title_full_unstemmed | Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report |
| title_short | Evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male: a case report |
| title_sort | evolutive radiological findings in a case of coccidioidal infection in an immunocompetent male a case report |
| topic | Coccidioidomycosis Osteomyelitis Synovitis Joint effusion Bone erosion Fungal |
| url | https://doi.org/10.1186/s42269-024-01297-w |
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