Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances
Abstract A strategy for the preparation of a hybrid chitosan/silica nanohydrogel is reported, which combines the gelation of chitosan in a nanoemulsion system with a sol–gel process to produce silica. Chitosan is used as a biopolymer matrix, while silica acts as a structuring additive. Hydrogel nano...
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Wiley-VCH
2025-01-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202400151 |
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| author | Asmaa M. Elzayat Katharina Landfester Rafael Muñoz‐Espí |
| author_facet | Asmaa M. Elzayat Katharina Landfester Rafael Muñoz‐Espí |
| author_sort | Asmaa M. Elzayat |
| collection | DOAJ |
| description | Abstract A strategy for the preparation of a hybrid chitosan/silica nanohydrogel is reported, which combines the gelation of chitosan in a nanoemulsion system with a sol–gel process to produce silica. Chitosan is used as a biopolymer matrix, while silica acts as a structuring additive. Hydrogel nanocapsules are obtained through the ionic interaction of the cationic groups of chitosan with the anionic groups of sodium triphosphate (STP), which is used as a physical cross‐linker. Two alternative preparation methods are compared in this work: in the first one, STP is added to the continuous phase of an inverse emulsion of chitosan; in the second one, the fusion of droplets of two emulsions containing separate chitosan and STP takes place. The size of the obtained nanocapsules ranges from 50 to 200 nm. The efficiency of the formed hydrogel for entrapping a hydrophilic model substance (erioglaucine disodium salt) is investigated for the two systems by studying the release in a neutral aqueous medium. The results indicate that the hydrophilic cargo is efficiently encapsulated by both preparation methods, although the droplet‐fusion method yields more stable suspensions. As a general observation, the release behavior of erioglaucine is systematically retarded when silica is present in the systems. |
| format | Article |
| id | doaj-art-2c541b397fbc41f8aafb9de2bca30fed |
| institution | Kabale University |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-2c541b397fbc41f8aafb9de2bca30fed2025-01-13T15:24:25ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-01-013101n/an/a10.1002/mame.202400151Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic SubstancesAsmaa M. Elzayat0Katharina Landfester1Rafael Muñoz‐Espí2Institute of Materials Science (ICMUV) Universitat de València C/ Catedràtic José Beltrán 2 Paterna 46980 SpainMax Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz GermanyInstitute of Materials Science (ICMUV) Universitat de València C/ Catedràtic José Beltrán 2 Paterna 46980 SpainAbstract A strategy for the preparation of a hybrid chitosan/silica nanohydrogel is reported, which combines the gelation of chitosan in a nanoemulsion system with a sol–gel process to produce silica. Chitosan is used as a biopolymer matrix, while silica acts as a structuring additive. Hydrogel nanocapsules are obtained through the ionic interaction of the cationic groups of chitosan with the anionic groups of sodium triphosphate (STP), which is used as a physical cross‐linker. Two alternative preparation methods are compared in this work: in the first one, STP is added to the continuous phase of an inverse emulsion of chitosan; in the second one, the fusion of droplets of two emulsions containing separate chitosan and STP takes place. The size of the obtained nanocapsules ranges from 50 to 200 nm. The efficiency of the formed hydrogel for entrapping a hydrophilic model substance (erioglaucine disodium salt) is investigated for the two systems by studying the release in a neutral aqueous medium. The results indicate that the hydrophilic cargo is efficiently encapsulated by both preparation methods, although the droplet‐fusion method yields more stable suspensions. As a general observation, the release behavior of erioglaucine is systematically retarded when silica is present in the systems.https://doi.org/10.1002/mame.202400151chitosandrug releasehybridhydrogelsminiemulsionsilica |
| spellingShingle | Asmaa M. Elzayat Katharina Landfester Rafael Muñoz‐Espí Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances Macromolecular Materials and Engineering chitosan drug release hybrid hydrogels miniemulsion silica |
| title | Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances |
| title_full | Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances |
| title_fullStr | Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances |
| title_full_unstemmed | Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances |
| title_short | Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances |
| title_sort | chitosan silica hybrid nanogels by inverse nanoemulsion for encapsulating hydrophilic substances |
| topic | chitosan drug release hybrid hydrogels miniemulsion silica |
| url | https://doi.org/10.1002/mame.202400151 |
| work_keys_str_mv | AT asmaamelzayat chitosansilicahybridnanogelsbyinversenanoemulsionforencapsulatinghydrophilicsubstances AT katharinalandfester chitosansilicahybridnanogelsbyinversenanoemulsionforencapsulatinghydrophilicsubstances AT rafaelmunozespi chitosansilicahybridnanogelsbyinversenanoemulsionforencapsulatinghydrophilicsubstances |