Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.

Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.

Dengue viruses (DENV) are enveloped single-stranded positive-sense RNA viruses transmitted by Aedes spp. mosquitoes. There are four genetically distinct serotypes designated DENV-1 through DENV-4, each further subdivided into distinct genotypes. The dengue scientific community has long contended tha...

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Bibliographic Details
Main Authors: William B Messer, Boyd Yount, Kari E Hacker, Eric F Donaldson, Jeremy P Huynh, Aravinda M de Silva, Ralph S Baric
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001486&type=printable
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