Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects

Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects

BackgroundFor patients with epilepsy, antiseizure medication remains the primary treatment; however, it is ineffective in approximately 30% of cases. These patients experience progressive neuronal damage and poor outcomes. Therefore, there is an urgent need for disease-modifying therapy (DMT) that t...

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Bibliographic Details
Main Authors: Lei Wei, Sijie Ou, Youshi Meng, Lanfeng Sun, Lin Zhang, Yuling Lu, Yuan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
epilepsy
glycyrrhizin
pyroptosis
disease-modifying therapy
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1530735/full
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