Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial
Abstract The management of overactive bladder (OAB) in women encompasses a range of strategies, from behavioral modifications to pharmacotherapy and nerve stimulation techniques. This prospective, randomized, controlled trial evaluates the efficacy of the combination of TTNS and mirabegron in sympto...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-78492-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846171943949041664 |
|---|---|
| author | Ya-Xiong Xu Yu Xiong Hong-qiang Tian Yan-hao Yang Rong-zhen Tao Yun-Peng Li |
| author_facet | Ya-Xiong Xu Yu Xiong Hong-qiang Tian Yan-hao Yang Rong-zhen Tao Yun-Peng Li |
| author_sort | Ya-Xiong Xu |
| collection | DOAJ |
| description | Abstract The management of overactive bladder (OAB) in women encompasses a range of strategies, from behavioral modifications to pharmacotherapy and nerve stimulation techniques. This prospective, randomized, controlled trial evaluates the efficacy of the combination of TTNS and mirabegron in symptom improvement over three months in women diagnosed with OAB. The study was designed as a randomized controlled trial. A total of 40 patients were prospectively randomized into two groups. Twenty patients in the combination group accepted TTNS and mirabegron therapy, and the other 20 patients as control only accepted mirabegron therapy. Primary outcomes were changes from baseline in the lower urinary tract symptoms. The severity of symptoms and quality of life (QoL) were assessed using the validated OAB questionnaire (OAB-q). TTNS reduced the clinical symptoms of OAB, and the difference was statistically significant at all study sites (p < 0.05). Regarding secondary outcomes, the OAB-q symptom bother score was lower in the combination group than in the mirabegron group (p < 0.05). The OAB-q score in the combination group was statistically superior to that in the mirabegron group (p < 0.05). The incidence of complications was not statistically significant between the two groups.The combination of TTNS and mirabegron represents a promising therapeutic strategy for women with overactive bladder, significantly improving symptoms and quality of life with a favorable safety profile. Further research with a larger sample size and long-term follow-up is warranted to confirm these findings and explore the underlying mechanisms of this combination therapy’s efficacy. |
| format | Article |
| id | doaj-art-2c13577abe1f49ef878f9fb7cd58c74d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2c13577abe1f49ef878f9fb7cd58c74d2024-11-10T12:23:40ZengNature PortfolioScientific Reports2045-23222024-11-011411810.1038/s41598-024-78492-2Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trialYa-Xiong Xu0Yu Xiong1Hong-qiang Tian2Yan-hao Yang3Rong-zhen Tao4Yun-Peng Li5Department of Gynecology and obstetrics, The Second Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The Fourth Affiliated Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityAbstract The management of overactive bladder (OAB) in women encompasses a range of strategies, from behavioral modifications to pharmacotherapy and nerve stimulation techniques. This prospective, randomized, controlled trial evaluates the efficacy of the combination of TTNS and mirabegron in symptom improvement over three months in women diagnosed with OAB. The study was designed as a randomized controlled trial. A total of 40 patients were prospectively randomized into two groups. Twenty patients in the combination group accepted TTNS and mirabegron therapy, and the other 20 patients as control only accepted mirabegron therapy. Primary outcomes were changes from baseline in the lower urinary tract symptoms. The severity of symptoms and quality of life (QoL) were assessed using the validated OAB questionnaire (OAB-q). TTNS reduced the clinical symptoms of OAB, and the difference was statistically significant at all study sites (p < 0.05). Regarding secondary outcomes, the OAB-q symptom bother score was lower in the combination group than in the mirabegron group (p < 0.05). The OAB-q score in the combination group was statistically superior to that in the mirabegron group (p < 0.05). The incidence of complications was not statistically significant between the two groups.The combination of TTNS and mirabegron represents a promising therapeutic strategy for women with overactive bladder, significantly improving symptoms and quality of life with a favorable safety profile. Further research with a larger sample size and long-term follow-up is warranted to confirm these findings and explore the underlying mechanisms of this combination therapy’s efficacy.https://doi.org/10.1038/s41598-024-78492-2Transcutaneous tibial nerve stimulationMirabegronOveractive bladderCombination therapyQuality of life |
| spellingShingle | Ya-Xiong Xu Yu Xiong Hong-qiang Tian Yan-hao Yang Rong-zhen Tao Yun-Peng Li Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial Scientific Reports Transcutaneous tibial nerve stimulation Mirabegron Overactive bladder Combination therapy Quality of life |
| title | Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial |
| title_full | Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial |
| title_fullStr | Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial |
| title_full_unstemmed | Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial |
| title_short | Efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial |
| title_sort | efficacy of the combination of transcutaneous tibial nerve stimulation and mirabegron in women with overactive bladder in a prospective randomized controlled trial |
| topic | Transcutaneous tibial nerve stimulation Mirabegron Overactive bladder Combination therapy Quality of life |
| url | https://doi.org/10.1038/s41598-024-78492-2 |
| work_keys_str_mv | AT yaxiongxu efficacyofthecombinationoftranscutaneoustibialnervestimulationandmirabegroninwomenwithoveractivebladderinaprospectiverandomizedcontrolledtrial AT yuxiong efficacyofthecombinationoftranscutaneoustibialnervestimulationandmirabegroninwomenwithoveractivebladderinaprospectiverandomizedcontrolledtrial AT hongqiangtian efficacyofthecombinationoftranscutaneoustibialnervestimulationandmirabegroninwomenwithoveractivebladderinaprospectiverandomizedcontrolledtrial AT yanhaoyang efficacyofthecombinationoftranscutaneoustibialnervestimulationandmirabegroninwomenwithoveractivebladderinaprospectiverandomizedcontrolledtrial AT rongzhentao efficacyofthecombinationoftranscutaneoustibialnervestimulationandmirabegroninwomenwithoveractivebladderinaprospectiverandomizedcontrolledtrial AT yunpengli efficacyofthecombinationoftranscutaneoustibialnervestimulationandmirabegroninwomenwithoveractivebladderinaprospectiverandomizedcontrolledtrial |