Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior
Abstract Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by alterations in social communication and repetitive behaviors. Advanced maternal age is associated with an increased risk of bearing children affected by autism but the etiological factors underlying this ass...
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| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-82070-x |
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| author | Marta Marlena Ziętek Aneta Jaszczyk Adrian Mateusz Stankiewicz Silvestre Sampino |
| author_facet | Marta Marlena Ziętek Aneta Jaszczyk Adrian Mateusz Stankiewicz Silvestre Sampino |
| author_sort | Marta Marlena Ziętek |
| collection | DOAJ |
| description | Abstract Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by alterations in social communication and repetitive behaviors. Advanced maternal age is associated with an increased risk of bearing children affected by autism but the etiological factors underlying this association are not well known. Here, we investigated the effects of advanced maternal age on offspring health and behavior in two genetically divergent mouse strains: the BTBR T+ Itpr3tf/J (BTBR) mouse model of idiopathic autism, and the C57BL/6 J (B6) control strain, as a model of genetic variability. In both strains, advanced maternal age negatively affected female reproductive and pregnancy outcomes, and perturbed placental and fetal growth, and the expression of genes in the fetal brain tissues. Postnatally, advanced maternal age had strain-dependent effects on offspring sociability, learning skills, and the occurrence of perseverative behaviors, varying between male and female offspring. These findings disentangle the relationship between genetic determinants and maternal age-related factors in shaping the emergence of autism-like behaviors in mice, highlighting the interplay between maternal age, genetic variability, and prenatal programming, in the occurrence of neurodevelopmental disorders. |
| format | Article |
| id | doaj-art-2c0999f01fc4438d960c1b9da587fb29 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2c0999f01fc4438d960c1b9da587fb292025-01-05T12:31:02ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-82070-xPrenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behaviorMarta Marlena Ziętek0Aneta Jaszczyk1Adrian Mateusz Stankiewicz2Silvestre Sampino3Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of SciencesDepartment of Animal Behavior and Welfare, Institute of Genetics and Animal Biotechnology of the Polish Academy of SciencesDepartment of Animal Behavior and Welfare, Institute of Genetics and Animal Biotechnology of the Polish Academy of SciencesDepartment of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of SciencesAbstract Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by alterations in social communication and repetitive behaviors. Advanced maternal age is associated with an increased risk of bearing children affected by autism but the etiological factors underlying this association are not well known. Here, we investigated the effects of advanced maternal age on offspring health and behavior in two genetically divergent mouse strains: the BTBR T+ Itpr3tf/J (BTBR) mouse model of idiopathic autism, and the C57BL/6 J (B6) control strain, as a model of genetic variability. In both strains, advanced maternal age negatively affected female reproductive and pregnancy outcomes, and perturbed placental and fetal growth, and the expression of genes in the fetal brain tissues. Postnatally, advanced maternal age had strain-dependent effects on offspring sociability, learning skills, and the occurrence of perseverative behaviors, varying between male and female offspring. These findings disentangle the relationship between genetic determinants and maternal age-related factors in shaping the emergence of autism-like behaviors in mice, highlighting the interplay between maternal age, genetic variability, and prenatal programming, in the occurrence of neurodevelopmental disorders.https://doi.org/10.1038/s41598-024-82070-xAdvanced maternal agePregnancyBehaviorAutismBTBR mice |
| spellingShingle | Marta Marlena Ziętek Aneta Jaszczyk Adrian Mateusz Stankiewicz Silvestre Sampino Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior Scientific Reports Advanced maternal age Pregnancy Behavior Autism BTBR mice |
| title | Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior |
| title_full | Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior |
| title_fullStr | Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior |
| title_full_unstemmed | Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior |
| title_short | Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior |
| title_sort | prenatal gene environment interactions mediate the impact of advanced maternal age on mouse offspring behavior |
| topic | Advanced maternal age Pregnancy Behavior Autism BTBR mice |
| url | https://doi.org/10.1038/s41598-024-82070-x |
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