Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS.

Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS.

Previous genome-wide association studies (GWAS) have identified various risk variants for ulcerative colitis (UC), but there is a lack of evidence showing how these variants contribute to the development of UC. We employed an integrated pipeline to effectively translate genetic associations in order...

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Main Authors: Ningning Liu, Yi Hou, Miao Yu, Gaihong Liu, Yingxue Xu, Qiang Jiang, Dongli Wang, Lianzhu Wang, Yujie Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0324035
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