Inhibiting neddylation: A new strategy for tumor therapy

Inhibiting neddylation: A new strategy for tumor therapy

Neddylation is a crucial posttranslational modification that involves the attachment of neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to a lysine residue in the substrate via the sequential actions of the E1 NEDD8-activating enzyme (NAE) (E1), E2 NEDD8-conjugating e...

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Bibliographic Details
Main Authors: Jian Sun, Cui Liu, Changhui Lang, Jing Wang, Qingxiang Li, Chang Peng, Zuochen Du, Yan Chen, Pei Huang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Neddylation
Tumor
Antitumor
Inhibitor
PPI
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924002375
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