Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities
Abstract Green nanotechnology is an effective treatment approach being used in cancer research with less adverse effects. This work describes the incorporation of silver nanoparticles synthesized from clitoria ternatea plant extract (Ag@CT NPs) into sodium alginate and gelatin polymer blends (SA/GEL...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-79003-z |
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| author | Vyshnavi T. Veetil Vidhu Jayakrishnan Vaisakh Aravindan Anakha D. Rajeeve Sreekanth Koolath Ramasamy Yamuna |
| author_facet | Vyshnavi T. Veetil Vidhu Jayakrishnan Vaisakh Aravindan Anakha D. Rajeeve Sreekanth Koolath Ramasamy Yamuna |
| author_sort | Vyshnavi T. Veetil |
| collection | DOAJ |
| description | Abstract Green nanotechnology is an effective treatment approach being used in cancer research with less adverse effects. This work describes the incorporation of silver nanoparticles synthesized from clitoria ternatea plant extract (Ag@CT NPs) into sodium alginate and gelatin polymer blends (SA/GEL) to produce Ag@CT-SA/GEL polymer beads using calcium chloride (CaCl2) crosslinking agent. Both the formation and the effective incorporation of Ag@CT NPs into polymer blend have been proven by various spectroscopic analysis, surface morphology study and energy dispersive X-ray analysis. Ag@CT NPs and Ag@CT-SA/GEL demonstrate good antibacterial and antioxidant activities comparable to commercially available drug. Dimethyl thiazolyl tetrazolium bromide (MTT) anticancer assay and apoptosis study of plant extract and Ag@CT NPs against lung cancer cell lines clearly indicate that Ag@CT-SA/GEL polymer bead can serve as an effective anticancer agent. |
| format | Article |
| id | doaj-art-2b9df43d2f9b436f8e06b0cff19057b7 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-2b9df43d2f9b436f8e06b0cff19057b72024-11-10T12:18:35ZengNature PortfolioScientific Reports2045-23222024-11-0114111410.1038/s41598-024-79003-zBiogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activitiesVyshnavi T. Veetil0Vidhu Jayakrishnan1Vaisakh Aravindan2Anakha D. Rajeeve3Sreekanth Koolath4Ramasamy Yamuna5Department of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa VidyapeethamDepartment of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa VidyapeethamDepartment of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa VidyapeethamDepartment of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa VidyapeethamDepartment of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa VidyapeethamDepartment of Chemistry, Amrita School of Physical Sciences, Amrita Vishwa VidyapeethamAbstract Green nanotechnology is an effective treatment approach being used in cancer research with less adverse effects. This work describes the incorporation of silver nanoparticles synthesized from clitoria ternatea plant extract (Ag@CT NPs) into sodium alginate and gelatin polymer blends (SA/GEL) to produce Ag@CT-SA/GEL polymer beads using calcium chloride (CaCl2) crosslinking agent. Both the formation and the effective incorporation of Ag@CT NPs into polymer blend have been proven by various spectroscopic analysis, surface morphology study and energy dispersive X-ray analysis. Ag@CT NPs and Ag@CT-SA/GEL demonstrate good antibacterial and antioxidant activities comparable to commercially available drug. Dimethyl thiazolyl tetrazolium bromide (MTT) anticancer assay and apoptosis study of plant extract and Ag@CT NPs against lung cancer cell lines clearly indicate that Ag@CT-SA/GEL polymer bead can serve as an effective anticancer agent.https://doi.org/10.1038/s41598-024-79003-zSilver nanoparticleSodium alginateGelatinAnticancerAntioxidantAntibacterial |
| spellingShingle | Vyshnavi T. Veetil Vidhu Jayakrishnan Vaisakh Aravindan Anakha D. Rajeeve Sreekanth Koolath Ramasamy Yamuna Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities Scientific Reports Silver nanoparticle Sodium alginate Gelatin Anticancer Antioxidant Antibacterial |
| title | Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities |
| title_full | Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities |
| title_fullStr | Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities |
| title_full_unstemmed | Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities |
| title_short | Biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities |
| title_sort | biogenic silver nanoparticles incorporated hydrogel beads for anticancer and antibacterial activities |
| topic | Silver nanoparticle Sodium alginate Gelatin Anticancer Antioxidant Antibacterial |
| url | https://doi.org/10.1038/s41598-024-79003-z |
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